ArticleCureus2023
The Missed Opportunity: HIV, Hepatitis C Virus (HCV), and Hepatitis B Virus (HBV) Positive Patients in Neoadjuvant and Perioperative Immunotherapy Clinical Trials for Lung Cancer.
Article in Cureus, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This editorial addresses a critical oversight in recent clinical trials on neoadjuvant or perioperative immunotherapy for lung cancer, the exclusion of patients with human immunodeficiency virus (HIV), hepatitis C virus (HCV), and hepatitis B virus (HBV). The ethical implications of this exclusion are highlighted, demonstrating how it undermines principles of inclusivity and equity in clinical research. We emphasize the necessity to include these patients to enhance the generalizability of trial findings. We suggest that trial eligibility criteria be revised, and collaborations with patient advocacy groups be initiated to ensure more inclusive future trials. This approach aims to uphold ethical research practices, yielding robust, representative data, and ultimately improving patient care in oncology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.