Evidence map›Paper›PMID 38161360›Full record

ArticleACS central science2023

Biocatalytic Construction of Chiral Pyrrolidines and Indolines via Intramolecular C(sp

Zi-Yang Qin, Shilong Gao, Yike Zou, Zhen Liu, James B Wang, Kendall N Houk, Frances H Arnold

Open access · diamondAbstract read
In one paragraph

Article in ACS central science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 24 citations in OpenAlex.

  1. Design-Evolution Synergy Enables New-to-Nature Enzyme Chemistry.bioRxiv : the preprint server for biology · 2026
    Article
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  7. Enzyme-catalyzed C(spRSC advances · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Zi-Yang QinDivision of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, United States.ORCID https://orcid.org/0000-0001-7356-6927
Shilong GaoDivision of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, United States.ORCID https://orcid.org/0000-0003-2808-6283
Yike ZouDepartment of Chemistry and Biochemistry, University of California, Los Angeles, California 90095, United States.ORCID https://orcid.org/0000-0003-4380-7827
Zhen LiuDivision of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, United States.ORCID https://orcid.org/0000-0002-1119-0693
James B WangDivision of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, United States.ORCID https://orcid.org/0000-0003-4085-3035
Kendall N HoukDepartment of Chemistry and Biochemistry, University of California, Los Angeles, California 90095, United States.ORCID https://orcid.org/0000-0002-8387-5261
Frances H ArnoldDivision of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, United States.ORCID https://orcid.org/0000-0002-4027-364X
California Institute of Technology · USUniversity of California, Los Angeles · US

Funding

Breakthrough Molecular Dynamics Research via an Anton2 SupercomputerR01GM116961 · NIGMS · CARNEGIE-MELLON UNIVERSITY · PI BLOOD, PHILIP D. · 2016 to 2023
$3.0M
NIGMS NIH HHS R01 GM116961
6 · The paper itself

Abstract

Nature harnesses exquisite enzymatic cascades to construct

Identifiers

PMID38161360
PMCPMC10755850
OpenAlexW4389721525

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.