ArticleNutrition, metabolism, and cardiovascular diseases : NMCD2024
Association of diabetes and glycemic control with left atrial function: The Atherosclerosis Risk in Communities (ARIC) study.
Article in Nutrition, metabolism, and cardiovascular diseases : NMCD, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 3 citations in OpenAlex.
- Effect of glycemic status on the natural history of left atrial structure and function in adults with metabolic syndrome and obesity.International journal of cardiology · 2026Observational
- Article
- The predictive power of left atrial reservoir strain for long-term atrial fibrillation in the Atherosclerosis Risk in Communities study.Heart rhythm · 2025Article
- Small left ventricular size as a predictor for incident type 2 diabetes: insights from the UK biobank cardiovascular magnetic resonance substudy.Diabetology & metabolic syndrome · 2025Article
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Authors and funding
12 authors at 6 institutions in 2 countries.
Funding
Abstract
BACKGROUND AND
aimsAlthough glycemic status is associated with impaired cardiac structure and function, less is known on left atrial (LA) function across the glycemic spectrum. We evaluated the association of diabetes and glycemic control with LA function in a community-based cohort of older adults. METHODS AND
resultsThis cross-sectional analysis included 5075 participants from the Atherosclerosis Risk in Communities Study (mean age 75.5 years, 58 % women, and 20 % Black adults) with echocardiographic strain data for LA reservoir, conduit, and contractile function. Multivariable linear regression was used to assess associations of diabetes status and glycemic control with LA function. In participants without diabetes, we used ordinal linear regression to evaluate associations of fasting glucose and HbA1c with LA function. Compared to individuals with a normal fasting glucose, prevalent diabetes was associated with 0.68 % lower LA conduit function (95 % confidence interval (CI): 1.11 to -0.25) and prediabetes a 0.47 % reduction (95 % CI: 0.85 to -0.09) in fully adjusted analyses. Persons with diabetes and high HbA1c (HgbA1c ≥ 7 % vs <7 %) had 1.05 % lower LA conduit function (95 % CI: 1.63, -0.48). Among individuals without diagnosed diabetes, higher fasting glucose, but not HbA1c, was significantly associated with worse LA conduit function. No significant associations were observed for LA reservoir and contractile function.
conclusionsA history of diabetes, prediabetes, and higher fasting glucose levels in persons without diabetes were associated with worse LA conduit function. Corroborative research is needed in prospective cohorts as well as studies that explore underlying mechanisms.
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