Evidence map›Paper›PMID 38160612›Full record

ArticleJournal of Ayurveda and integrative medicine

Pharmaceutical characterization and exploration of Arkeshwara rasa in MDA-MB-231 cells.

Remya Jayakumar, Manoj Kumar Dash, Pankaj Kumar, Shiwakshi Sharma, Saumya Gulati, Akanksha Pandey, Kaushavi Cholke, Zeeshan Fatima, S K Trigun, Namrata Joshi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Ayurveda and integrative medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.8field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Remya JayakumarDepartment of Rasashastra and Bhaishajya Kalpana, Banaras Hindu University, Varanasi, 221005, India.
Manoj Kumar DashDepartment of Rasashastra and Bhaishajya Kalpana, Government Ayurveda College, Raipur, India. Electronic address: drmanojkumardash@gmail.com.
Pankaj KumarDepartment of Rasashastra and Bhaishajya Kalpana, Banaras Hindu University, Varanasi, 221005, India.
Shiwakshi SharmaDepartment of Rasashastra and Bhaishajya Kalpana, Banaras Hindu University, Varanasi, 221005, India.
Saumya GulatiDept of Rasashastra and Bhaishjya Kalpana, Babu Yugraj Singh Ayurvedic Medical College and Hospital, Gomtinagar Extension, Sector 6 Lucknow, Uttar Pradesh, 226010, India.
Akanksha PandeyDepartment of Zoology, Institute of Science, Banaras Hindu University, Varanasi, 221005, India.
Kaushavi CholkeAmity Lipidomics Research Facility (ALRF), Amity University, Haryana, Manesar, Gurugram, 122413, India; Institute of Biochemistry and Molecular Medicine, University of Bern, 3012, Switzerland.
Zeeshan FatimaDepartment of Medical Laboratory Sciences, College of Applied Medical Sciences, University of Bisha, Bisha, 61922, Saudi Arabia; Amity Institute of Biotechnology, Amity University, Haryana, Manesar, Gurugram, 122413, India.
S K TrigunDepartment of Zoology, Institute of Science, Banaras Hindu University, Varanasi, 221005, India.
Namrata JoshiDepartment of Rasashastra and Bhaishajya Kalpana, Banaras Hindu University, Varanasi, 221005, India.
Banaras Hindu University · INDesh Bhagat Ayurvedic College and Hospital · INUniversity of Bern · CHUniversity of Bisha · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe diverse specificity mode of cancer treatment targets and chemo resistance demands the necessity of drug entities which can address the devastating dynamicity of the disease.

objectivesTo check the anti-tumour potential of traditional medicine rich in polyherbal components and metal nanoparticle namely Arkeshwara rasa (AR). MATERIAL

methodsThe AR was prepared in a modified version with reference from Rasaratna Samuchaya and characterized using sophisticated instrumental analysis including XRD, SEM-EDAX, TEM, TGA-DSC, and LC-MS and tested against the MDA-MB-231 cell line to screen cell viability and the cytotoxicity with MTT, SRB and the AO assay.

resultsXRD pattern shows cubic tetrahedrite structure with Sb, Cu, S peaks and trace elements like Fe, Mg, etc. The particle size of AR ranges between 20 and 30 nm. The TGA points thermal decomposition at 210 °C and the metal sulphide peaks in DSC. LC-MS analysis reveals the components of the formulation more on the flavonoid portion. The IC

conclusionsThe Hesperidine, Neohesperidin, Rutin components in the phytochemical pool can synergize the anti-tumour potential with either influencing cellular pathways or decreasing chemo resistance to conventional treatment. AR need to be further experimented with reverse transcription, flow cytometry, western blotting, etc.

Indexed as

Arkeshwara rasaCancerHesperidinIC(50) valueIn-vitroTraditional medicine

Identifiers

PMID38160612
PMCPMC10792653
OpenAlexW4390439855

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.