ArticleJournal of Alzheimer's disease : JAD2024
Association Between Reduced Posterior Occlusal Contact and Alzheimer's Disease Onset in Older Japanese Adults: Results from the LIFE Study.
Article in Journal of Alzheimer's disease : JAD, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.
- Dentition-Cognition Relationship in Aging Populations: A Meta-Analysis of Longitudinal Data.Journal of oral rehabilitation · 2026Pooled it
- Reduced Posterior Occlusal Contacts Are Associated With an Increased Risk of Stroke: A Retrospective Study Based on a Japanese Claims Database.Journal of the American Heart Association · 2026Article
- Association between masticatory function and cognitive ability in mild cognitive impairment.BMC geriatrics · 2026Article
- Role of Posterior Occlusal Support in the Development of Frailty Among Japanese Adults: A Longitudinal Cohort Study.Geriatrics & gerontology international · 2026Article
- Oral diseases as emerging risk factors for Alzheimer's disease: A scoping review.The Japanese dental science review · 2025Review
- Impact of posterior occlusal contact loss on cardiovascular disease using a Japanese claims database.Scientific reports · 2025Article
- Association Between Undernutrition and the Number of Molar Occlusions in Older Persons Requiring Care in Long-Term Care Insurance Facilities.Nutrients · 2025Article
- Longitudinal association between posterior occlusal contact and dementia development in a large retrospective cohort study using a Japanese claims database.Scientific reports · 2024Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAn association between poor oral health and cognitive decline has been reported. Most of these studies have considered the number of teeth as a criterion, only a few studies have analyzed the relationship between occlusal status and Alzheimer's disease (AD).
objectiveTo elucidate whether posterior occlusal contact is associated with AD, focusing on the Eichner classification, among an older population aged 65 years or older in Japan.
methodsThis study used monthly claims data of National Health Insurance in Japan from April 2017 to March 2020. The outcome was newly diagnosed AD defined according to ICD-10 code G30. The number of teeth was estimated by dental code data, and occlusal contact was divided into three categories, namely A, B, and C, according to the Eichner classification. Multivariate Cox proportional hazards models were used to analyze the association between a new diagnosis of AD and the Eichner classification.
resultsA total of 22,687 participants were included, 560 of whom had newly diagnosed AD during a mean follow-up period of 12.2 months. The AD participants had a lower proportion of Eichner A and a higher proportion of Eichner C. After adjusting for covariates, hazard ratios (95% confidence intervals) with Eichner B and C were 1.34 (1.01-1.77) and 1.54 (1.03-2.30), respectively.
conclusionIn older people aged≥65 years old, reduced posterior occlusal contact as well as tooth loss have an impact on AD. This study emphasizes the importance of paying attention to occlusal contacts to reduce the risk of AD.
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