Evidence map›Paper›PMID 38159171›Full record

ArticleMolecular biotechnology2024

Overexpression of circZNF720 Inhibits Hepatocellular Carcinoma Progression by Regulating miR-421/MAPK9.

Feifei Yang, Zhenjuan Zhuang, Chunying Liu, Fuliang Li, Jingjing Zhou

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Article in Molecular biotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Feifei YangDepartment of Pathology, Anqiu People's Hospital, No. 159 Xuefu street, Anqiu, Weifang, 262100, Shandong, China.
Zhenjuan ZhuangDepartment of Pathology, Anqiu People's Hospital, No. 159 Xuefu street, Anqiu, Weifang, 262100, Shandong, China.
Chunying LiuDepartment of Ultrasonic Diagnosis, Anqiu people's Hospital, Anqiu, 262100, Shandong, China.
Fuliang LiDepartment of Pathology, Anqiu People's Hospital, No. 159 Xuefu street, Anqiu, Weifang, 262100, Shandong, China.
Jingjing ZhouDepartment of Pathology, Anqiu People's Hospital, No. 159 Xuefu street, Anqiu, Weifang, 262100, Shandong, China. zhoujingjing0709@163.com.ORCID http://orcid.org/0000-0002-1637-1354

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) is characterized by high incidence, high death rate and poor long term prognosis. Abnormal expression of circular RNA (circRNA) has been demonstrated to be closely associated with malignant progression of HCC. However, the effect of circZNF720 on HCC is largely incompletely understood. This study sought to explore the effect of circZNF720 on the progression of HCC by CCK-8, transwell, and flow cytometry experiments. The prognosis of circZNF720 on patients was analyzed by Kaplan-Meier curve. Then, the regulatory mechanisms among circZNF720, miR-421, and MAPK9 were identified by qRT-PCR, dual-luciferase reporter assay, and RIP analysis, respectively. The outcomes of this study disclosed that circZNF720 was lowly expressed in HCC, and this low expression was strongly linked with a poor prognosis for HCC patients. Overexpression of circZNF720 inhibited the proliferation, migration, and invasion of cells, and increased the apoptosis of cells. Mechanistic studies revealed that circZNF720 targeted miR-421 and regulated the development of HCC by acting as a sponge for miRNAs. In addition, MAPK9 was a downstream target of miR-421, and circZNF720 introduction hampered HCC progression by upregulating MAPK9 expression through sponging miR-421. In conclusion, circZNF720 restrained HCC progression by targeting miR-421/MAPK9. This study provides a novel target for the treatment of HCC.

Indexed as

ApoptosisCarcinoma, HepatocellularCell MovementCell ProliferationGene Expression Regulation, NeoplasticLiver NeoplasmsMicroRNAsRNA, CircularCell Line, TumorDisease ProgressionFemaleHumansMaleMiddle AgedPrognosisMicroRNAsMIRN421 microRNA, humanRNA, CircularcircZNF720Hepatocellular CarcinomaMAPK9miR-421

Identifiers

PMID38159171

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.