Evidence map›Paper›PMID 38159161›Full record

ArticlePsychopharmacology2024

The imidazoline I

Justin N Siemian, Kristen Woodhouse, David H Liu, Yanan Zhang, Jun-Xu Li

Open access · greenAbstract read
In one paragraph

Article in Psychopharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Examining the impact of maternal oxycodone self-administration during gestation in a translational model.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Justin N SiemianDepartment of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA.
Kristen WoodhouseDepartment of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA.
David H LiuEpiscopal High School, Alexandria, VA, USA.
Yanan ZhangResearch Triangle Institute, Research Triangle Park, NC, USA.
Jun-Xu LiDepartment of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA. junxuli@buffalo.edu.ORCID http://orcid.org/0000-0001-8103-7013
University at Buffalo, State University of New York · USEpiscopal High School · USRTI International · US

Funding

IMIDAZOLINE I2 RECEPTORS AS TARGETS FOR THE TREATMENT OF PAINR01DA034806 · NIDA · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI LI, JUN-XU · 2013 to 2017
$1.7M
NIDA NIH HHS R01 DA034806NIDA NIH HHS R01DA034806
6 · The paper itself

Abstract

rationaleIncreasing evidence shows that imidazoline I

objectivesThe von Frey filament test was used to determine the antinociceptive effects of 2-BFI (intravenous, i.v.) in a rat model of complete Freund's adjuvant (CFA)-induced inflammatory pain. IV self-administration was used to assess the reinforcing effects of 2-BFI alone and to assess the effects of non-contingent injections of 2-BFI (i.p.) on morphine self-administration. A two-lever drug discrimination paradigm in which rats were trained to discriminate 3.2 mg/kg morphine (i.p.) from saline was used to examine whether 2-BFI or another I

results2-BFI could not maintain reliable self-administration behavior in rats with no pain or CFA-treated inflammatory pain. However, pretreatment with 2-BFI (i.p.) produced dose-dependent decreases in the dose-effect curve of morphine self-administration. Both 2-BFI and BU224 did not substitute for morphine but significantly attenuated the discriminative stimulus effects of morphine.

conclusionsThese results suggest that I

Indexed as

BenzofuransImidazolesImidazolinesMorphineAnalgesics, OpioidAnimalsDose-Response Relationship, DrugImidazoline ReceptorsPainRatsRats, Sprague-Dawley2-(2-benzofuranyl)-2-imidazolineAnalgesics, OpioidBenzofuransImidazolesImidazoline ReceptorsImidazolinesMorphineAntinociceptionDrug discriminationImidazoline I2 receptorMorphineRatsSelf-administration

Identifiers

PMID38159161
PMCPMC11955926
OpenAlexW4390442354

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.