Evidence map›Paper›PMID 38159159›Full record

ArticleClinical oral investigations2023

Investigating the potential clinical impact of periodontitis on the progression of Alzheimer's disease: a prospective cohort study.

Kubra Karaduran, Ahmet Aydogdu, Ozlem Gelisin, Sadiye Gunpinar

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Clinical oral investigations, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05807100 (Analyzing the Relationship Between Periodontal Health Status and Alzheimer's Disease), which is not on this map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05807100 completednot on this map

Analyzing the Relationship Between Periodontal Health Status and Alzheimer's Disease

Typeobservational_patient_registrySponsorBezmialem Vakif UniversityRan2022 to 2023Enrolled90ConditionsAlzheimer Disease, Periodontal DiseasesArmsBaseline Standardized Mini Mental Test, 6th month Standardized Mini Mental Test
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Kubra KaraduranFaculty of Dentistry, Department of Periodontology, Bezmialem Vakif University, Istanbul, Turkey. kubra95krdrn@gmail.com.
Ahmet AydogduFaculty of Dentistry, Department of Periodontology, Istanbul Galata University, Istanbul, Turkey.
Ozlem GelisinDepartment of Neurology, Istanbul Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey.
Sadiye GunpinarFaculty of Dentistry, Department of Periodontology, Bezmialem Vakif University, Istanbul, Turkey.
Bezmiâlem Vakıf Üniversitesi · TRBakırköy Dr.Sadi Konuk Eğitim ve Araştırma Hastanesi · TRİstanbul Galata Üniversitesi

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThis study aimed to investigate the effect of periodontitis and current occlusal relationship on the progression rate of Alzheimer's disease (AD).

methodsNinety Alzheimer's patients, who were divided into three groups as Stage I (n=42), Stage II (n=29), and Stage III (n=19), based on the Clinical Dementia Rating Scale, were included in the study. Cognitive status of the patients was evaluated with Standardized Mini-Mental Test (SMMT) at baseline and repeated 6 months later. Clinical periodontal examinations were recorded and occlusal relationship status was classified according to the Eichner Index.

resultsOf 90 Alzheimer's patients, 65 were toothed individuals with periodontitis and 25 were edentulous individuals without active periodontal disease. Stage II and Stage III toothed Alzheimer's patients had higher percentage of bleeding on probing (BOP%) and clinical attachment level (CAL) values than Stage I patients (p<0.05). Stage III Alzheimer's patients had significantly higher probing pocket depth (PPD) values than Stage I individuals (p<0.05). ΔSMMT values showed positive correlation with BOP% (r=0.308, p=0.013) and PPD (r=0.275, p=0.027). Among the evaluated parameters, being in the AD Stage II-Stage III, having periodontitis and age variable had significant effects on ΔSMMT levels (p<0.05).

conclusionsWithin the limits of our study, it can be concluded that periodontitis may increase the severity and also accelerate the progression rate of AD. CLINICAL RELEVANCE: These results are precious to show the necessity of proper oral hygiene activities and regular dental visits in patients with toothed AD. CLINICAL

trial registrationThis study was registered and approved by clinical trials (NCT05807100).

Indexed as

Alzheimer DiseasePeriodontitisHumansPeriodontal PocketProspective StudiesAlzheimer’s diseaseChewingCognitive declineOcclusionPeriodontal diseasePeriodontitis

Identifiers

PMID38159159
OpenAlexW4390444520

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.