ArticleApplied biochemistry and biotechnology2024
NDRG2 Promotes Lens Epithelial Cells Senescence via NLRP3/Caspase1-Mediated Pyroptosis.
Article in Applied biochemistry and biotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed, 2 citations in OpenAlex.
- Lens epithelial cells senescence in cataract pathogenesis and emerging therapeutic opportunities.Frontiers in cell and developmental biology · 2026Review
- Diagnostic value and immune microenvironment regulatory network of metabolic reprogramming in chronic rhinosinusitis with nasal polyps identified by multidimensional transcriptome integration and machine learning.Frontiers in immunology · 2026Article
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1 author at 1 institution in 1 country.
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Abstract
objectThis study aims to investigate the molecular mechanism of NDRG2 (N-myc downstream-regulated gene 2) in the cell senescence of lens endothelial cells.
methodsLens endothelial cells (SRA01/04) were irradiated with UVB at different times. Cell viability was measured by CCK-8 kit and cell cycle was detected by flow cytometry. Cell senescence was detected using SA-β-gal staining. Western blot was utilized to detect the expressions of p53, p21 and NDRG2. TUNEL staining and flow cytometry were used to detect apoptosis and pyroptosis.
resultsUVB-irradiation significantly induces cell senescence and the expression of NDRG2, p53 and p21 in SRA01/04 cells was up-regulated. Down-regulation of NDRG2 inhibited UVB-induced cell senescence, significantly reversed pyroptosis and promoted cell proliferation. UVB-induced pyroptosis is closely related to caspase-1/NLRP3 axis.
conclusionOur study confirmed downregulation of NDRG2 significantly inhibited UVB radiation-induced cell senescence by regulating caspase-1/NLRP3-mediated pyroptosis.
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