Evidence map›Paper›PMID 38158471›Full record

ArticleMolecular biology reports2023

PABPN1 functions as a predictive biomarker in colorectal carcinoma.

Qing-Hua Wang, Pei-Ci Yan, Li-Zhou Shi, Ya-Jie Teng, Xiao-Jiao Gao, Li-Qian Yao, Zhi-Wei Liang, Ming-Hui Zhou, Wei Han, Rui Li

Abstract read
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In one paragraph

Article in Molecular biology reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Qing-Hua WangDepartment of Gastroenterology, The First Affiliated Hospital of Soochow University, Suzhou, 215006, Jiangsu, People's Republic of China.
Pei-Ci YanDepartment of Gastroenterology, Kunshan First People's Hospital Affiliated to Jiangsu University, Kunshan, 215300, Jiangsu, People's Republic of China.
Li-Zhou ShiDepartment of General Surgery, Kunshan First People's Hospital Affiliated to Jiangsu University, Kunshan, 215300, Jiangsu, People's Republic of China.
Ya-Jie TengDepartment of Gastroenterology, Kunshan First People's Hospital Affiliated to Jiangsu University, Kunshan, 215300, Jiangsu, People's Republic of China.
Xiao-Jiao GaoDepartment of Pathology, Kunshan First People's Hospital Affiliated to Jiangsu University, Kunshan, 215300, Jiangsu, People's Republic of China.
Li-Qian YaoDepartment of Pathology, Kunshan First People's Hospital Affiliated to Jiangsu University, Kunshan, 215300, Jiangsu, People's Republic of China.
Zhi-Wei LiangCentral Laboratory, Kunshan First People's Hospital Affiliated to Jiangsu University, Kunshan, 215300, Jiangsu, People's Republic of China.
Ming-Hui ZhouCentral Laboratory, Kunshan First People's Hospital Affiliated to Jiangsu University, Kunshan, 215300, Jiangsu, People's Republic of China.
Wei HanDepartment of General Surgery, Kunshan First People's Hospital Affiliated to Jiangsu University, Kunshan, 215300, Jiangsu, People's Republic of China. hans64@126.com.
Rui LiDepartment of Gastroenterology, The First Affiliated Hospital of Soochow University, Suzhou, 215006, Jiangsu, People's Republic of China. Lirui_Soochow@tom.com.
First People's Hospital of Kunshan · CNJiangsu University · CNFirst Affiliated Hospital of Soochow University · CNSoochow University · CN

Funding

Suzhou Municipal Bureau on Science and Technology SKJY2021012
6 · The paper itself

Abstract

purposePABPN1 acts as a modulator of poly(A) tail length and alternative polyadenylation. This research was aimed to explore the role of PABPN1 in colorectal cancer (CRC).

methodsPublic databases were performed to analyze expression, location, roles of prognosis and tumor immunity and interaction with RNAs and proteins of PABPN1. To investigate PABPN1 expression in tissues, 78 CRC specimens were collected to conduct IHC, and 30 pairs of frozen CRC and corresponding adjacent normal tissues were used to conduct qRT-PCR and WB. In addition, in vitro experiments were then carried out to identify the role of PABPN1 in CRC.

resultsCompared with normal tissues, PABPN1 expression was significant higher in CRC. Its high level predicted poor outcome of CRC. Th1 and Treg had significant negative relationships not only with PABPN1 expression, but also with six molecules interacting with PABPN1, including IFT172, KIAA0895L, RECQL4, WDR6, PABPC1 and NCBP1. In addition, PABPN1 had negative relationships with quite a few immune markers, such as CSF1R, IL-10, CCL2 and so on. In cellular experiments, silencing PABPN1 inhibited proliferation and promoted apoptosis in HCT-116 CRC cells.

conclusionIn summary, PABPN1 might become a novel biomarker and correlate with tumor immunity in CRC.

Indexed as

Colorectal NeoplasmsRNAAdaptor Proteins, Signal TransducingBiomarkersCell Line, TumorCell ProliferationCytoskeletal ProteinsHCT116 CellsHumansPoly(A)-Binding Protein IRNA, MessengerAdaptor Proteins, Signal TransducingBiomarkersCytoskeletal ProteinsIFT172 protein, humanPABPN1 protein, humanPoly(A)-Binding Protein IRNARNA, MessengerBioinformaticsColorectal cancerPABPN1Tumor immunity

Identifiers

PMID38158471
OpenAlexW4390402638

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.