Evidence map›Paper›PMID 38158430›Full record

Observational studyMolecular biology reports2023

Association between vitamin D receptor gene FokI polymorphism and mortality in patients with sepsis.

Sukriye Miray Kilincer Bozgul, Durdugul Ayyildiz Emecen, Funda Karbek Akarca, Devrim Bozkurt, Ozgur Aydin, Didem Koca, Ozge Can, Omer Vedat Unalp, Tahir Atik

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Molecular biology reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. The Role of Vitamin D and Vitamin D Receptor in Sepsis.Current issues in molecular biology · 2025
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sukriye Miray Kilincer BozgulFaculty of Medicine, Department of Internal Medicine, Ege University, Izmir, Turkey.
Durdugul Ayyildiz EmecenFaculty of Medicine, Department of Pediatrics, Division of Pediatric Genetics, Ege University, Izmir, Turkey.
Funda Karbek AkarcaFaculty of Medicine, Department of Emergency Medicine, Ege University, 35100, Bornova, Izmır, Turkey. fundakarbek@gmail.com.ORCID https://orcid.org/0000-0003-2455-8044
Devrim BozkurtFaculty of Medicine, Department of Internal Medicine, Ege University, Izmir, Turkey.
Ozgur AydinFaculty of Medicine, Department of Internal Medicine, Ege University, Izmir, Turkey.
Didem KocaFaculty of Medicine, Department of Internal Medicine, Ege University, Izmir, Turkey.
Ozge CanFaculty of Medicine, Department of Emergency Medicine, Ege University, 35100, Bornova, Izmır, Turkey.
Omer Vedat UnalpDepartment of General Surgeon, KTO Karatay University, Konya, Turkey.
Tahir AtikFaculty of Medicine, Department of Pediatrics, Division of Pediatric Genetics, Ege University, Izmir, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSepsis is life-threatening organ dysfunction as a result of the host's dysregulated immune response to infection. The vitamin D receptor (VDR) gene FokI polymorphism influences immune cell behavior. In the present study, we aimed to investigate the association between VDR FokI polymorphism and mortality in sepsis and non-sepsis patients in the intensive care unit (ICU). METHODS AND

resultsThis is a prospective observational study involving 96 sepsis and 96 non-sepsis patients admitted to the Ege University ICU. VDR FokI polymorphisms were investigated, as well as the relationship between the identified polymorphisms and mortality.  In-hospital mortality was 27.1% in the sepsis group and 8.33% in the non-sepsis group (p = 0.001). The frequencies of VDR FokI TT, TC, and CC genotypes were 8 (8.33%), 48 (50.0%), and 40 (41.7%) in the sepsis group, and 11 (11.5%), 42 (43.8%), and 43 (44.8%) in the non-sepsis group, respectively (p = 0.612). In the sepsis group, the frequencies of Fokl TT, TC, and CC genotypes did not differ significantly between survivors and non-survivors. However, homozygous C allele carriers had lower overall mortality (p = 0.047).

conclusionThe VDR FokI polymorphism, particularly the CC genotype, appears to be associated with lower mortality in ICU patients.

Indexed as

Receptors, CalcitriolSepsisAllelesCase-Control StudiesGenetic Predisposition to DiseaseGenotypeHumansPolymorphism, GeneticPolymorphism, Single NucleotideVitamin DReceptors, CalcitriolVitamin DFokIMortalityPolymorphismSepsisVitamin D receptor

Identifiers

PMID38158430

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.