ArticleNature methods2024
Multigroup analysis of compositions of microbiomes with covariate adjustments and repeated measures.
Article in Nature methods, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07232550 (Biomarkers and Respiratory Omics as New CHildren Opportunities - Study of Clinical Outcomes and Predictivity Evaluation - a Multi-cohort, Multi-center Study), which is not on this map. Cited by 347 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Biomarkers and Respiratory Omics as New CHildren Opportunities - Study of Clinical Outcomes and Predictivity Evaluation - a Multi-cohort, Multi-center Study
Who cites it
347 citing papers in PubMed, 1 synthesis or guideline pooled it, 350 citations in OpenAlex.
- A network-based meta-analysis of the honeybee gut microbiome: geographic, seasonal, and pesticide-associated shifts.Scientific reports · 2026Pooled it
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- Regional species turnover and local host and forest stand characteristics jointly structure early foliar mycobiomes of Scots pine seedlings.FEMS microbiology ecology · 2026Article
- Lactiplantibacillus Plantarum CKDB008 and Lacticaseibacillus Rhamnosus LDTM7511 Attenuate Visceral Hypersensitivity and Suppress Serum IgE in an Acetic Acid-Induced IBS-Like Rat Model.Probiotics and antimicrobial proteins · 2026Article
- The biliary microbiome in symptomatic cholelithiasis: a prospective comparison across distinct bacterial niches.BMC microbiology · 2026Observational
- Community-wide adaptive evolution of gut bacteria during dietary transitions.bioRxiv : the preprint server for biology · 2026Article
- Host and Environmental Factors Outweigh Pathogen in Shaping Skin Microbiome of a Threatened Andean Amphibian Community.Molecular ecology · 2026Article
- Review
- The Adult Aedes aegypti Bacterial Microbiota is Robust to Infection with the Obligate Microsporidian Parasite Edhazardia aedis.Environmental microbiology · 2026Article
- Lung microbiome features associated with ICU delirium in mechanically ventilated patients: a secondary cohort analysis.Brain, behavior, & immunity - health · 2026Article
- Comparative metataxonomic analysis of total, viable, and active rumen microbial communities under methane-mitigated conditions.Environmental microbiome · 2026Article
- Gut Microbial Topology and Metabolic Signatures Associated With Colorectal Neoplasia.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Article
- Multi-kingdom gut microbiota analyses identify biomarkers of different types of pediatric short bowel syndrome.mSystems · 2026Article
- Gastric Microbiota from Populations with High Risk of Gastric Cancer in Nariño, Colombia.International journal of molecular sciences · 2026Article
- Unique Oral Microbiota Signatures and Neurocognitive Function in Adolescents with and without Perinatally Acquired HIV.Research square · 2026Article
- Soil microbial responses to long-term agricultural practices under no-till: insights from depth-resolved sampling of shallow soil layers.FEMS microbiology ecology · 2026Article
- Hashimoto's thyroiditis influences tumor cell states and intratumoral microbiota in papillary thyroid carcinoma.iScience · 2026Article
- Functional capacities drive recruitment of bacteria into plant root microbiota.Nature microbiology · 2026Article
287 more citing papers are in PubMed but not listed here.
Corrections and comments
- Update of
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Microbiome differential abundance analysis methods for two groups are well-established in the literature. However, many microbiome studies involve more than two groups, sometimes even ordered groups such as stages of a disease, and require different types of comparison. Standard pairwise comparisons are inefficient in terms of power and false discovery rates. In this Article, we propose a general framework, ANCOM-BC2, for performing a wide range of multigroup analyses with covariate adjustments and repeated measures. We illustrate our methodology through two real datasets. The first example explores the effects of aridity on the soil microbiome, and the second example investigates the effects of surgical interventions on the microbiome of patients with inflammatory bowel disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.