Evidence map›Paper›PMID 38158416›Full record

ArticleNature communications2023

Targeted treatment of injured nestmates with antimicrobial compounds in an ant society.

Erik T Frank, Lucie Kesner, Joanito Liberti, Quentin Helleu, Adria C LeBoeuf, Andrei Dascalu, Douglas B Sponsler, Fumika Azuma, Evan P Economo, Patrice Waridel and 3 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
7.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. Article
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  5. The First of Us:bioRxiv : the preprint server for biology · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Feeding ecology and behavioral adaptations shape injury patterns in central European ants.Behavioral ecology : official journal of the International Society for Behavioral Ecology
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 5 countries.

Erik T FrankDepartment of Ecology and Evolution, Biophore, University of Lausanne, CH-1015, Lausanne, Switzerland. erik.frank@uni-wuerzburg.de.ORCID 0000-0002-2066-3202
Lucie KesnerDepartment of Fundamental Microbiology, Biophore, University of Lausanne, CH-1015, Lausanne, Switzerland.ORCID 0000-0002-2151-2457
Joanito LibertiDepartment of Ecology and Evolution, Biophore, University of Lausanne, CH-1015, Lausanne, Switzerland.ORCID 0000-0002-4158-2591
Quentin HelleuDepartment of Ecology and Evolution, Biophore, University of Lausanne, CH-1015, Lausanne, Switzerland.ORCID 0000-0003-0103-9786
Adria C LeBoeufDepartment of Biology, University of Fribourg, CH-1700, Fribourg, Switzerland.ORCID 0000-0002-2931-1510
Andrei DascaluDepartment of Ecology and Evolution, Biophore, University of Lausanne, CH-1015, Lausanne, Switzerland.
Douglas B SponslerDepartment of Animal Ecology and Tropical Biology, Biocenter, University of Würzburg, D-97074, Würzburg, Germany.
Fumika AzumaBiodiversity and Biocomplexity Unit, Okinawa Institute of Science and Technology Graduate University, Onna, 904-0495, Japan.
Evan P EconomoBiodiversity and Biocomplexity Unit, Okinawa Institute of Science and Technology Graduate University, Onna, 904-0495, Japan.
Patrice WaridelProtein Analysis Facility, Génopode, University of Lausanne, CH-1015, Lausanne, Switzerland.ORCID 0000-0001-7248-5105
Philipp EngelDepartment of Fundamental Microbiology, Biophore, University of Lausanne, CH-1015, Lausanne, Switzerland.ORCID 0000-0002-4678-6200
Thomas SchmittDepartment of Animal Ecology and Tropical Biology, Biocenter, University of Würzburg, D-97074, Würzburg, Germany.ORCID 0000-0002-6719-8635
Laurent KellerDepartment of Ecology and Evolution, Biophore, University of Lausanne, CH-1015, Lausanne, Switzerland. laurentkeller01@gmail.com.
University of Lausanne · CHUniversity of Würzburg · DECentre National de la Recherche Scientifique · FRHarvard University · USOkinawa Institute of Science and Technology Graduate University · JPUniversity of Fribourg · CH

Funding

Deutsche Forschungsgemeinschaft (German Research Foundation) 511474012EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council) 741491Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation) 310030_156732Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation) PR00P3_179776
6 · The paper itself

Abstract

Infected wounds pose a major mortality risk in animals. Injuries are common in the ant Megaponera analis, which raids pugnacious prey. Here we show that M. analis can determine when wounds are infected and treat them accordingly. By applying a variety of antimicrobial compounds and proteins secreted from the metapleural gland to infected wounds, workers reduce the mortality of infected individuals by 90%. Chemical analyses showed that wound infection is associated with specific changes in the cuticular hydrocarbon profile, thereby likely allowing nestmates to diagnose the infection state of injured individuals and apply the appropriate antimicrobial treatment. This study demonstrates that M. analis ant societies use antimicrobial compounds produced in the metapleural glands to treat infected wounds and reduce nestmate mortality.

Indexed as

Anti-Infective AgentsAntsAnimalsHydrocarbonsSocial BehaviorAnti-Infective AgentsHydrocarbons

Identifiers

PMID38158416
PMCPMC10756881
OpenAlexW4390405721

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.