Evidence map›Paper›PMID 38157992›Full record

ArticleBrain research bulletin2024

Brain endothelial CD200 signaling protects brain against ischemic damage.

Afzal Misrani, Conelius Ngwa, Abdullah Al Mamun, Romana Sharmeen, Kanaka Valli Manyam, Rodney M Ritzel, Louise McCullough, Fudong Liu

RetractedOpen access · goldAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain research bulletin, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Afzal MisraniDepartment of Neurology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Conelius NgwaDepartment of Neurology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Abdullah Al MamunDepartment of Neurology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Romana SharmeenDepartment of Neurology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Kanaka Valli ManyamDepartment of Neurology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Rodney M RitzelDepartment of Neurology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Louise McCulloughDepartment of Neurology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Fudong LiuDepartment of Neurology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA. Electronic address: Fudong.Liu@uth.tmc.edu.
The University of Texas Health Science Center at Houston · USThe University of Texas Health Science Center · US

Funding

Contribution of the X Chromosome to Sex Differences in StrokeR01NS108779 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI LIU, FUDONG, MCCULLOUGH, LOUISE D. · 2018 to 2022
$2.7M
CD200 signaling mediates the interactions of neurons and endothelia with circulating leukocytes in strokeR01NS129977 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Fudong Liu · 2023 to 2026
$2.2M
NINDS NIH HHS R01 NS108779NINDS NIH HHS R01 NS129977
6 · The paper itself

Abstract

Ischemic stroke induced inflammatory responses contribute significantly to neuronal damage and stroke outcomes. CD200 ligand and its receptor, CD200R, constitute an endogenous inhibitory signaling that is being increasingly recognized in studies of neuroinflammation in various central nervous system disorders. CD200 is a type 1 membrane glycoprotein that is broadly expressed by endothelia and neurons in the brain. In the present study, we have examined the role of endothelial CD200 signaling in acute ischemic stroke. Endothelial CD200 conditional knock out (CKO) mice were generated by breeding CD200 gene floxed mice with Cdh5

Indexed as

Brain IschemiaIschemic StrokeStrokeAnimalsAntigens, CDBrainInfarctionInfarction, Middle Cerebral ArteryMiceMice, KnockoutMicrogliaAntigens, CDantigens, CD200BBBEndothelial CD200Neurological functionStroke

Identifiers

PMID38157992
PMCPMC11022665
OpenAlexW4390349693

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.