Evidence map›Paper›PMID 38157154›Full record

ArticleApplied biochemistry and biotechnology2024

In Vitro and In Silico Studies on 4-Nitroacetophenone Thiosemicarbazone Potential Cytotoxicity Against A549 Cell Lines.

Neha Verma, Mohini Singh, Piyush Bhati, Sonia Khanna, Mohd Tashfeen Ashraf, Shilpa Kumari, Nidhi Chatterjee, Vishal K Deshwal, Sarvesh Rustagi, Kanu Priya

Abstract read
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In one paragraph

Article in Applied biochemistry and biotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Neha Verma *Department of Life Sciences, School of Basic Sciences and Research, Sharda University, Knowledge park-III, Greater Noida, U.P., 201310, India.
Mohini SinghDepartment of Life Sciences, School of Basic Sciences and Research, Sharda University, Knowledge park-III, Greater Noida, U.P., 201310, India.
Piyush BhatiSchool of Biotechnology, Gautam Buddha University, Greater Noida, U.P., 201312, India.
Sonia KhannaDepartment of Chemistry, School of Basic Sciences and Research, Sharda University, Knowledge park-III, Greater Noida, U.P., 201310, India.
Mohd Tashfeen AshrafSchool of Biotechnology, Gautam Buddha University, Greater Noida, U.P., 201312, India.
Shilpa KumariDepartment of Life Sciences, School of Basic Sciences and Research, Sharda University, Knowledge park-III, Greater Noida, U.P., 201310, India.
Nidhi ChatterjeeDepartment of Life Sciences, Guru Nanak College of Pharmaceutical Sciences, Dehradun, Uttarakhand, India.
Vishal K DeshwalDepartment of Life Sciences, Guru Nanak College of Pharmaceutical Sciences, Dehradun, Uttarakhand, India.
Sarvesh RustagiSchool of Applied and Life Sciences, Uttaranchal University, Dehradun, Uttarakhand, India.
Kanu Priya *Department of Life Sciences, School of Basic Sciences and Research, Sharda University, Knowledge park-III, Greater Noida, U.P., 201310, India. kanu.priya@sharda.ac.in.
Sharda University · INGautam Buddha University · INUttaranchal University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lung malignancy is a major worldwide issue that occurs due to the dysregulation of various growth factors. Lung cancer has no apparent signs in the early stages, which makes it harder to catch it in time and leads to a higher fatality rate. So, the goal of this work was to create and analyze a novel chemical molecule called 4-nitro acetophenone thiosemicarbazone (4-NAPTSc) against the lung cancer cell line A549 and human non-tumorigenic lung epithelial cell line BAES-2B. The ligand was synthesized by refluxing the reaction mixture of 4-nitro acetophenone and thiosemicarbazide and was further characterized by UV, FTIR, and

Indexed as

AcetophenonesMolecular Docking SimulationThiosemicarbazonesA549 CellsAntineoplastic AgentsErbB ReceptorsHumansLung NeoplasmsAcetophenonesAntineoplastic AgentsEGFR protein, humanErbB ReceptorsThiosemicarbazonesA549 lung cancer cell linesAnti-cancerCytotoxicityMolecular dockingThiosemicarbazone

Identifiers

PMID38157154
OpenAlexW4390410661

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.