Evidence map›Paper›PMID 38157153›Full record

ArticleApplied biochemistry and biotechnology2024

Comparative Analysis of Inhibitor Binding to Peroxiredoxins from Candidatus Liberibacter asiaticus and Its Host Citrus sinensis.

Deena Nath Gupta, Sapna Lonare, Ruchi Rani, Ankur Singh, Dilip Kumar Ghosh, Shailly Tomar, Ashwani Kumar Sharma

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Applied biochemistry and biotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Deena Nath GuptaDepartment of Biosciences and Bioengineering, Indian Institute of Technology Roorkee, Roorkee, 247667, India.
Sapna LonareDepartment of Biosciences and Bioengineering, Indian Institute of Technology Roorkee, Roorkee, 247667, India.
Ruchi RaniDepartment of Biosciences and Bioengineering, Indian Institute of Technology Roorkee, Roorkee, 247667, India.
Ankur SinghDepartment of Biosciences and Bioengineering, Indian Institute of Technology Roorkee, Roorkee, 247667, India.
Dilip Kumar GhoshPlant Virology Laboratory, ICAR Central Citrus Research Institute, Nagpur, India.
Shailly TomarDepartment of Biosciences and Bioengineering, Indian Institute of Technology Roorkee, Roorkee, 247667, India.
Ashwani Kumar SharmaDepartment of Biosciences and Bioengineering, Indian Institute of Technology Roorkee, Roorkee, 247667, India. ashwani.sharma@bt.iitr.ac.in.ORCID http://orcid.org/0000-0002-1180-056X
Indian Institute of Technology Roorkee · INCentral Citrus Research Institute · IN

Funding

Department of Biotechnology, Ministry of Science and Technology, India BT/PR9877/BRB/10/1274/2014
6 · The paper itself

Abstract

The peroxiredoxins (Prxs), potential drug targets, constitute an important class of antioxidant enzymes present in both pathogen and their host. The comparative binding potential of inhibitors to Prxs from pathogen and host could be an important step in drug development against pathogens. Huanglongbing (HLB) is a most devastating disease of citrus caused by Candidatus Liberibacter asiaticus (CLa). In this study, the binding of conoidin-A (conoidin) and celastrol inhibitor molecules to peroxiredoxin of bacterioferritin comigratory protein family from CLa (CLaBCP) and its host plant peroxiredoxin from Citrus sinensis (CsPrx) was assessed. The CLaBCP has a lower specific activity than CsPrx and is efficiently inhibited by conoidin and celastrol molecules. The biophysical studies showed conformational changes and significant thermal stability of CLaBCP in the presence of inhibitor molecules as compared to CsPrx. The surface plasmon resonance (SPR) studies revealed that the conoidin and celastrol inhibitor molecules have a strong binding affinity (K

Indexed as

Citrus sinensisPentacyclic TriterpenesPeroxiredoxinsBacterial ProteinsEnzyme InhibitorsLiberibacterMolecular Docking SimulationProtein BindingRhizobiaceaeSurface Plasmon ResonanceTriterpenesBacterial ProteinscelastrolEnzyme InhibitorsPentacyclic TriterpenesPeroxiredoxinsTriterpenesCircular dichroismDifferential scanning calorimetryInhibitor moleculesMolecular dynamics simulationsPeroxiredoxinsSurface plasmon resonance

Identifiers

PMID38157153
OpenAlexW4390406663

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.