Evidence map›Paper›PMID 38157073›Full record

ArticleMikrochimica acta2023

Surface Bragg gratings of proteins patterned on integrated waveguides for (bio)chemical analysis.

Augusto Juste-Dolz, Estrella Fernández, Gloria Micó, Luis A Bru, Pascual Muñoz, Miquel Avella-Oliver, Daniel Pastor, Ángel Maquieira

Abstract read
PubMed Publisher
In one paragraph

Article in Mikrochimica acta, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Augusto Juste-DolzInstituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Universitat Politècnica de València, Universitat de València, 46022, Valencia, Spain.
Estrella FernándezInstituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Universitat Politècnica de València, Universitat de València, 46022, Valencia, Spain.
Gloria MicóPhotonics Research Labs, ITEAM, Universitat Politècnica de València, 46022, Valencia, Spain.
Luis A BruPhotonics Research Labs, ITEAM, Universitat Politècnica de València, 46022, Valencia, Spain.
Pascual MuñozPhotonics Research Labs, ITEAM, Universitat Politècnica de València, 46022, Valencia, Spain.
Miquel Avella-OliverInstituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Universitat Politècnica de València, Universitat de València, 46022, Valencia, Spain. miavol@upv.es.ORCID 0000-0002-7293-6989
Daniel PastorPhotonics Research Labs, ITEAM, Universitat Politècnica de València, 46022, Valencia, Spain. dpastor@dcom.upv.es.
Ángel MaquieiraInstituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Universitat Politècnica de València, Universitat de València, 46022, Valencia, Spain. amaquieira@qim.upv.es.

Funding

Generalitat Valenciana IDIFEDER/2021/046Generalitat Valenciana PROMETEO/2020/094Generalitat Valenciana PROMETEO/2021/015MCIN/AEI/10.13039/501100011033 PID2019-110713RB-I00MCIN/AEI/10.13039/501100011033 PID2019-110877GB-I00MCIN/AEI/10.13039/501100011033 TED2021-132584B-C21Ministerio de Economía y Competitividad TEC2016-80385-PUniversitat Politècnica de València PAID-06-22
6 · The paper itself

Abstract

The incorporation of biomacromolecules onto silicon waveguiding microstructures constitutes a growing trend that pushes towards compact and miniaturized biosensing systems. This paper presents the integration of one-dimensional periodic nanostructures of proteins on the surface of micrometric silicon waveguides for transducing binding events between biomacromolecules. The study demonstrates this new bioanalytical principle by experimental results and theoretical calculations, and proves that rib waveguides (1--1.6-µm width) together with protein gratings (495--515-nm period) display suitable spectral responses for this optical biosensing system. Protein assemblies of bovine serum albumin are fabricated on the surface of silicon nitride waveguides, characterized by electron microscopy, and their response is measured by optical frequency domain reflectometry along the fabrication process and the subsequent stages of the biorecognition assays. Detection and quantification limits of 0.3 and 3.7 µg·mL

Indexed as

Biosensing TechniquesNanostructuresOptical DevicesSerum Albumin, BovineSerum Albumin, BovineBiosensorDiffractionImmunoassayLabel-freeLab on a chipMicrometric silicon waveguidesOptical frequency domain reflectometry

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.