Evidence map›Paper›PMID 38156943›Full record

ArticleThe Journal of physiology2024

Chronic intermittent hypoxia remodels catecholaminergic nerve innervation in mouse atria.

Ariege Bizanti, Yuanyuan Zhang, Zulema Toledo, Kohlton T Bendowski, Scott W Harden, Anas Mistareehi, Jin Chen, David Gozal, Maci Heal, Richard Christie and 3 more

Open access · greenAbstract read
In one paragraph

Article in The Journal of physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Ariege BizantiBurnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL, USA.
Yuanyuan ZhangBurnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL, USA.
Zulema ToledoBurnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL, USA.
Kohlton T BendowskiBurnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL, USA.
Scott W HardenBurnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL, USA.ORCID 0000-0002-0757-1979
Anas MistareehiBurnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL, USA.
Jin ChenBurnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL, USA.
David GozalJoan C. Edwards School of medicine, Marshall University, Huntington, WV, USA.
Maci HealMBF Bioscience, Williston, Vermont, USA.
Richard ChristieAuckland Bioengineering Institute, University of Auckland, Auckland, New Zealand.
Peter J HunterAuckland Bioengineering Institute, University of Auckland, Auckland, New Zealand.ORCID 0000-0001-9665-4145
Julian F R PatonDepartment Physiology, Manaaki Manawa-the Centre for Heart Research, University of Auckland, Auckland, New Zealand.ORCID 0000-0001-7410-2913
Zixi Jack ChengBurnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL, USA.
University of Central Florida · USUniversity of Auckland · NZMarshall University · USMBF Bioscience (United States) · US

Funding

Multi-scale, multi-organ, multi-species SPARC map managementOT3OD025349 · OD · UNIVERSITY OF AUCKLAND · PI HUNTER, PETER JOHN, NICKERSON, DAVID PHILLIP · 2017 to 2024
$16.3M
Mechanisms of cardiac sympathetic hyperactivity in chronic heart failureR01HL137832 · NHLBI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Yu-Long Li · 2017 to 2026
$4.1M
Nociceptive Afferent Topographical Innervation of the Heart and StomachU01NS113867 · NINDS · UNIVERSITY OF CENTRAL FLORIDA · PI CHENG, ZIXI JACK · 2019 to 2021
$1.6M
Chronic Intermittent Hypoxia: Sympathetic and Intrinsic Cardiac GanglionicInnervationR15HL137143 · NHLBI · UNIVERSITY OF CENTRAL FLORIDA · PI CHENG, ZIXI JACK · 2018 to 2018
$431k
NHLBI NIH HHS R01 HL137832NHLBI NIH HHS R15 HL137143NIH HHS 2R01HL137832-05NIH HHS NIH R15 HL137143-01ANIH HHS OT3 OD025349NIH HHS U01 NS113867-01NINDS NIH HHS U01 NS113867
6 · The paper itself

Abstract

Chronic intermittent hypoxia (CIH, a model for sleep apnoea) is a major risk factor for several cardiovascular diseases. Autonomic imbalance (sympathetic overactivity and parasympathetic withdrawal) has emerged as a causal contributor of CIH-induced cardiovascular disease. Previously, we showed that CIH remodels the parasympathetic pathway. However, whether CIH induces remodelling of the cardiac sympathetic innervation remains unknown. Mice (male, C57BL/6J, 2-3 months) were exposed to either room air (RA, 21% O

Indexed as

HypertensionSleep Apnea SyndromesAnimalsHeart AtriaHypoxiaMaleMiceMice, Inbred C57BLatriachronic intermittent hypoxiaheartintrinsic cardiac gangliasympathetic axonstyrosine hydroxylase

Identifiers

PMID38156943
PMCPMC10842556
OpenAlexW4390403884

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.