Evidence map›Paper›PMID 38156861›Full record

ArticleAsian Pacific journal of cancer prevention : APJCP2023

Suppressor of Cytokine Signaling-3 Gene Polymorphisms and the Risk of Hepatocellular Carcinoma in Chronic Hepatitis C Patients in Egypt.

Amal El Sharnoby, Hanan M Bedair, Gamal Yousef S Raia, Nermeen Hamed, Aliaa Sabry, Fatma A Khalaf, Mohamed Rashed Abd Elhamed, Mohamed Abdel-Samiee

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Asian Pacific journal of cancer prevention : APJCP, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Evaluation of Circular RNA SMARCA5 as a Novel Biomarker for Hepatocellular Carcinoma.Asian Pacific journal of cancer prevention : APJCP · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Amal El SharnobyDepartment of Clinical Pathology, National Liver Institute, Menoufia University, Shebin El-Kom, Egypt.
Hanan M BedairDepartment of Clinical Pathology, National Liver Institute, Menoufia University, Shebin El-Kom, Egypt.
Gamal Yousef S RaiaDepartment of Clinical Pathology, National Liver Institute, Menoufia University, Shebin El-Kom, Egypt.
Nermeen HamedMinistry of Health and Population, Egypt.
Aliaa SabryDepartment of Hepatology and Gastroenterology, National Liver Institute, Menoufia University, Shebin El-Kom, Egypt.
Fatma A KhalafDepartment of Clinical Biochemistry, National Liver Institute, Menoufia University, Shebin El-Kom, Egypt.
Mohamed Rashed Abd ElhamedDepartment of Clinical Pathology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
Mohamed Abdel-SamieeDepartment of Hepatology and Gastroenterology, National Liver Institute, Menoufia University, Shebin El-Kom, Egypt.ORCID 0000 0002 8970 0286
Menoufia University · EGAl-Azhar University · EGMinistry of Health and Population · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHepatocellular carcinoma (HCC) contributes significantly to cancer mortalities worldwide. The association between a specific single nucleotide polymorphism (SNP) located within the SOCS3 gene as well as the likelihood of hepatocellular carcinoma (HCC) progression in individuals with chronic hepatitis C virus (CHC) was found to be significant. We aimed to study SOCS3 gene polymorphisms at rs4969168 and rs4969170and HCC susceptibility in individuals with CHC.

methodsThe current prospective study involved 111 subjects divided in to three groups (HCC, HCV with and with no cirrhosis, and apparently healthy individuals). Tumor staging was done using BCLC staging system. SOCS3 (rs4969168 and rs4969170) gene polymorphisms' analysis was done utilizing real-time polymerase chain reaction (RT-PCR) (via DNA extracted from all subjects). All subjects underwent a complete history, medical examination, and laboratory and radiological data collection.

resultsCompared to healthy controls, homozygous AA genotypes and heterozygous GA genotypes were substantially overrepresented in  HCC patients as well as those with CHCaccompanied by cirrhosis.AFP, smoking, glucose level, and AA genotype of rs4969170 might be critical significant parameters for HCC development.

conclusionSOCS3 gene polymorphisms at rs4969168 and rs4969170 are associated with HCC and liver fibrosis progression in the Egyptian population with CHC infection.

Indexed as

Carcinoma, HepatocellularHepatitis C, ChronicLiver NeoplasmsCase-Control StudiesCytokinesEgyptGenetic Predisposition to DiseaseGenotypeHumansLiver CirrhosisPolymorphism, Single NucleotideProspective StudiesSuppressor of Cytokine Signaling 3 ProteinCytokinesSOCS3 protein, humanSuppressor of Cytokine Signaling 3 ProteincytokineHepatitis C VirusHepatocellular carcinomaReal-Time Polymerase Chain ReactionSOCS3 Gene Polymorphisms

Identifiers

PMID38156861
PMCPMC10909104
OpenAlexW4390414399

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.