Evidence map›Paper›PMID 38156644›Full record

ArticleNeurorehabilitation and neural repair2024

Paired DBS and TMS Reveals Dentato-Cortical Facilitation Underlying Upper Extremity Movement in Chronic Stroke Survivors.

Xin Li, Kenneth B Baker, Kyle O'Laughlin, Jacqueline Chen, Olivia Hogue, Andre G Machado, Ela B Plow

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurorehabilitation and neural repair, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

  1. Trial
  2. Review
  3. [Research progress on the neuromodulation targets in stroke rehabilitation].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2026
    Review
  4. Review
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Xin LiDepartment of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.ORCID 0000-0002-4664-0244
Kenneth B BakerCenter for Neurological Restoration, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA.
Kyle O'LaughlinDepartment of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
Jacqueline ChenDepartment of Diagnostic Radiology, Imaging Institute, Cleveland Clinic, Cleveland, OH, USA.
Olivia HogueCenter for Neurological Restoration, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA.
Andre G MachadoCenter for Neurological Restoration, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA.
Ela B PlowDepartment of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
Cleveland Clinic · USCleveland Clinic Lerner College of Medicine · US

Funding

Deep cerebellar electrical stimulation for post-stroke motor recoveryUH3NS100543 · NINDS · CLEVELAND CLINIC LERNER COM-CWRU · PI BAKER, KENNETH B, MACHADO, ANDRE GUELMAN · 2016 to 2021
$4.9M
Contralaterally Controlled FES Combined with Brain Stimulation for Severe Upper limb HemiplegiaR01HD098073 · NICHD · CLEVELAND CLINIC LERNER COM-CWRU · PI PLOW, ELA B · 2019 to 2024
$3.1M
NICHD NIH HHS R01 HD098073NINDS NIH HHS UH3 NS100543
6 · The paper itself

Abstract

backgroundCerebellum shares robust di-synaptic dentato-thalamo-cortical (DTC) connections with the contralateral motor cortex. Preclinical studies have shown that DTC are excitatory in nature. Structural integrity of DTC is associated with better upper extremity (UE) motor function in people with stroke, indicating DTC are important for cerebellar influences on movement. However, there is a lack of understanding of physiologic influence of DTC in humans, largely due to difficulty in accessing the dentate nucleus.

objectiveCharacterize DTC physiology using dentate nucleus deep brain stimulation (DBS) combined with transcranial magnetic stimulation (TMS) in stroke.

methodsNine chronic stroke survivors with moderate-to-severe UE impairment (Fugl-Meyer 13-38) underwent a paired DBS-TMS experiment before receiving experimental dentate nucleus DBS in our first-in-human phase I trial (Baker et al., 2023, Nature Medicine). Conditioning DBS pulses were given to dentate nucleus 1 to 10 ms prior to supra-threshold TMS pulses given to ipsilesional motor cortex. Effects were assessed on motor evoked potentials (MEPs). Size of DBS-conditioned MEPs was expressed relative to TMS MEPs, where values >1 indicate facilitation.

resultsDentate nucleus DBS led to facilitation of MEPs at short-latency intervals (3.5 and 5 ms,

conclusionsOur in vivo investigation reveals for the first time in humans the intrinsic excitatory properties of DTC, which can serve as a novel therapeutic target for post-stroke motor recovery.

Indexed as

StrokeTranscranial Magnetic StimulationCerebellumClinical Trials, Phase I as TopicDiffusion Tensor ImagingEvoked Potentials, MotorHumansUpper Extremitycerebellar-cortical physiologycerebellumdeep brain stimulationdentate nucleusstroketranscranial magnetic stimulation

Identifiers

PMID38156644
PMCPMC10922453
OpenAlexW4390412065

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.