ArticleImmunity, inflammation and disease2023
Mucosal response of inactivated and recombinant COVID-19 vaccines in Congolese individuals.
Article in Immunity, inflammation and disease, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 4 citations in OpenAlex.
- Eight-year tuberculosis epidemic trends in the Republic of Congo, a high TB burden country: progress and gaps towards end-TB targets.BMJ global health · 2025Article
- Neutralizing antibody responses assessment after vaccination in people living with HIV using a surrogate neutralization assay.BMC immunology · 2024Article
- Mucosal response of inactivated and recombinant COVID-19 vaccines in Congolese individuals.Immunity, inflammation and disease · 2023Article
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Authors and funding
11 authors at 6 institutions in 5 countries.
Funding
Abstract
backgroundThe efficacy of immunization against an airborne pathogen depends in part on its ability to induce antibodies at the major entry site of the virus, the mucosa. Recent studies have revealed that mucosal immunity is poorly activated after vaccination with messenger RNA vaccines, thus failing in blocking virus acquisition upon its site of initial exposure. Little information is available about the induction of mucosal immunity by inactivated and recombinant coronavirus disease 2019 (COVID-19) vaccines. This study aims to investigate this topic.
methodsSaliva and plasma samples from 440 healthy Congolese were collected including (1) fully vaccinated 2 month postvaccination with either an inactivated or a recombinant COVID-19 vaccine and (2) nonvaccinated control group. Total anti-severe acute respiratory syndrome coronavirus 2 receptor-binding domain IgG and IgA antibodies were assessed using in-house enzyme-linked immunosorbent assays for both specimens.
findingsAltogether, the positivity of IgG was significantly higher in plasma than in saliva samples both in vaccinated and nonvaccinated control groups. Inversely, IgA positivity was slightly higher in saliva than in plasma of vaccinated group. The overall IgG and IgA levels were respectively over 10
conclusionInactivated and recombinant COVID-19 vaccines in use in the Republic of Congo poorly activated mucosal IgA-mediated antibody response 2 months postvaccination.
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