Evidence map›Paper›PMID 38155909›Full record

ArticleFrontiers in pharmacology2023

GABA

Pratap Meera, Mikko Uusi-Oukari, Gerald S Lipshutz, Martin Wallner

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Pyrroloquinoline Quinone and NADPharmaceuticals (Basel, Switzerland) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Pratap MeeraDepartment of Neurobiology, University of California, Los Angeles, Los Angeles, CA, United States.
Mikko Uusi-OukariIntegrative Physiology and Pharmacology, Institute of Biomedicine, University of Turku, Turku, Finland.
Gerald S LipshutzDepartment of Surgery, University of California, Los Angeles, Los Angeles, CA, United States.
Martin WallnerDepartment of Surgery, University of California, Los Angeles, Los Angeles, CA, United States.
University of California, Los Angeles · USUniversity of Turku · FI

Funding

Understanding the Mechanism and Preventing the Unique Neuropathology of Arginase DeficiencyR01NS110596 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LIPSHUTZ, GERALD S · 2019 to 2023
$1.7M
Cell and Gene Replacement Strategies for Arginase DeficiencyR01NS100979 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LIPSHUTZ, GERALD S · 2017 to 2021
$1.7M
Elucidation of the Role of the Arginase Isoforms in Normal Neuronal Development and FunctionR03NS114623 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LIPSHUTZ, GERALD S · 2020 to 2020
$156k
NINDS NIH HHS R01 NS100979NINDS NIH HHS R01 NS110596NINDS NIH HHS R03 NS114623
6 · The paper itself

Abstract

Dementia and autoimmune diseases are prevalent conditions with limited treatment options. Taurine and homotaurine (HT) are naturally occurring sulfonate amino acids, with taurine being highly abundant in animal tissues, but declining with age in the blood. HT is a blood-brain barrier permeable drug under investigation for Alzheimer's disease. HT also has beneficial effects in a mouse model of multiple sclerosis likely through an anti-inflammatory mechanism mediated by GABA

Indexed as

Alzheimer’s diseaseGABAA receptorGABA-mimeticshomotaurineinflammationtaurinetramiprosate

Identifiers

PMID38155909
PMCPMC10752957
OpenAlexW4389726951

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.