Evidence map›Paper›PMID 38155767›Full record

ArticleiScience2024

Inhibition of 7α,26-dihydroxycholesterol biosynthesis promotes midbrain dopaminergic neuron development.

James Hennegan, Aled H Bryant, Lauren Griffiths, Matthieu Trigano, Oliver J M Bartley, Joanna J Bartlett, Carys Minahan, Willy Antoni Abreu de Oliveira, Eylan Yutuc, Sotirios Ntikas and 11 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 5 institutions in 3 countries.

James HenneganRegenerative Neurobiology Laboratory, Swansea University Medical School, Institute of Life Science 1, Singleton Park, Swansea SA2 8PP, UK.
Aled H BryantRegenerative Neurobiology Laboratory, Swansea University Medical School, Institute of Life Science 1, Singleton Park, Swansea SA2 8PP, UK.
Lauren GriffithsRegenerative Neurobiology Laboratory, Swansea University Medical School, Institute of Life Science 1, Singleton Park, Swansea SA2 8PP, UK.
Matthieu TriganoDementia Research Institute, Cardiff University, Hadyn Ellis Building, Cardiff CF24 4HQ, UK.
Oliver J M BartleyBrain Repair Group, School of Biosciences, Cardiff University, Cardiff CF10 3AX, UK.
Joanna J BartlettRegenerative Neurobiology Laboratory, Swansea University Medical School, Institute of Life Science 1, Singleton Park, Swansea SA2 8PP, UK.
Carys MinahanSchool of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff CF10 3NB, UK.
Willy Antoni Abreu de OliveiraLaboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 17177 Stockholm, Sweden.
Eylan YutucOxysterol Research Group, Swansea University Medical School, ILS1 Building, Singleton Park, Swansea SA2 8PP, UK.
Sotirios NtikasRegenerative Neurobiology Laboratory, Swansea University Medical School, Institute of Life Science 1, Singleton Park, Swansea SA2 8PP, UK.
Christos S BartsocasAthens Medical Center, 15125 Athens, Greece.
Margarita MarkouriAthens Medical Center, 15125 Athens, Greece.
Eleni AntoniadouAthens Medical Center, 15125 Athens, Greece.
Ioanna LainaAthens Medical Center, 15125 Athens, Greece.
Owain W HowellMultiple Sclerosis Research Group, Swansea University Medical School, ILS1 Building, Singleton Park, Swansea SA2 8PP, UK.
Meng LiDementia Research Institute, Cardiff University, Hadyn Ellis Building, Cardiff CF24 4HQ, UK.
Yuqin WangOxysterol Research Group, Swansea University Medical School, ILS1 Building, Singleton Park, Swansea SA2 8PP, UK.
William J GriffithsOxysterol Research Group, Swansea University Medical School, ILS1 Building, Singleton Park, Swansea SA2 8PP, UK.
Emma L LaneSchool of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff CF10 3NB, UK.
Mariah J LelosBrain Repair Group, School of Biosciences, Cardiff University, Cardiff CF10 3AX, UK.
Spyridon TheofilopoulosRegenerative Neurobiology Laboratory, Swansea University Medical School, Institute of Life Science 1, Singleton Park, Swansea SA2 8PP, UK.
Swansea University · GBAthens Medical Center · GRCardiff University · GBUK Dementia Research Institute · GBKarolinska Institutet · SE

Funding

Medical Research Council MR/L010305/1Medical Research Council MR/R022429/1
6 · The paper itself

Abstract

Dysregulated cholesterol metabolism has been linked to neurodegeneration. We previously found that free, non-esterified, 7α,(25

Indexed as

Biological sciencesMolecular neuroscienceneuroscience

Identifiers

PMID38155767
PMCPMC10753067
OpenAlexW4389444005

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.