Evidence map›Paper›PMID 38155626›Full record

ArticleNagoya journal of medical science2023

T cell receptor-engineered T cells derived from target human leukocyte antigen-DPB1-specific T cell can be a potential tool for therapy against leukemia relapse following allogeneic hematopoietic cell transplantation.

Naoya Katsuyama, Takakazu Kawase, Carolyne Barakat, Shohei Mizuno, Akihiro Tomita, Kazutaka Ozeki, Nobuhiro Nishio, Yoshie Sato, Ryoko Kajiya, Keiko Shiraishi and 4 more

Open access · greenAbstract read
In one paragraph

Article in Nagoya journal of medical science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.5field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 1 country.

Naoya KatsuyamaDepartment of Immunology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Takakazu KawaseDepartment of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan.
Carolyne BarakatDepartment of Immunology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Shohei MizunoDivision of Hematology, Department of Internal Medicine, Aichi Medical University, Nagakute, Japan.
Akihiro TomitaDepartment of Hematology, Fujita Health University School of Medicine, Toyoake, Japan.
Kazutaka OzekiDepartment of Hematology and Oncology, JA Aichi Konan Kosei Hospital, Konan, Japan.
Nobuhiro NishioCenter for Advanced Medicine and Clinical Research, Department of Advanced Medicine, Nagoya University Hospital, Nagoya, Japan.
Yoshie SatoDepartment of Immunology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Ryoko KajiyaDepartment of Immunology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Keiko ShiraishiDepartment of Immunology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Yoshiyuki TakahashiDepartment of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Tatsuo IchinoheDepartment of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan.
Hiroyoshi NishikawaDepartment of Immunology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Yoshiki AkatsukaDepartment of Immunology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Nagoya University · JPHiroshima University · JPAichi Medical University · JPFujita Health University · JPKonan Kosei Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human leukocyte antigen (HLA)-DPB1 antigens are mismatched in approximately 70% of allogeneic hematopoietic stem cell transplantations (allo-HSCT) from HLA 10/10 matched unrelated donors. HLA-DP-mismatched transplantation was shown to be associated with an increase in acute graft-versus-host disease (GVHD) and a decreased risk of leukemia relapse due to the graft-versus-leukemia (GVL) effect. Immunotherapy targeting mismatched HLA-DP is considered reasonable to treat leukemia following allo-HCT if performed under non-inflammatory conditions. Therefore, we isolated CD4

Indexed as

Hematopoietic Stem Cell TransplantationLeukemiaChronic DiseaseHLA-DP beta-ChainsHumansPeptidesReceptors, Antigen, T-CellRecurrenceT-LymphocytesTransplantation, HomologousHLA-DPB1 antigenHLA-DP beta-ChainsPeptidesReceptors, Antigen, T-Cellallogeneic transplantationGVHDleukemiaTCR-T

Identifiers

PMID38155626
PMCPMC10751490
OpenAlexW4390419110

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.