Evidence map›Paper›PMID 38155473›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2024

Locus Coeruleus-Dorsolateral Septum Projections Modulate Depression-Like Behaviors via BDNF But Not Norepinephrine.

Qian Zhang, You Xue, Ke Wei, Hao Wang, Yuan Ma, Yao Wei, Yi Fan, Lei Gao, Hang Yao, Fangfang Wu and 6 more

Open access · goldAbstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 12 citations in OpenAlex.

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  9. A Comprehensive 4-layeredCurrent pharmaceutical biotechnology · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

Qian ZhangDepartment of Pharmacology, School of Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
You XueDepartment of Pharmacology, School of Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
Ke WeiDepartment of Pharmacology, School of Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
Hao WangDepartment of Pharmacology, School of Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
Yuan MaDepartment of Pharmacology, School of Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
Yao WeiDepartment of Pharmacology, School of Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
Yi FanDepartment of Neurology, Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing, 210024, China.
Lei GaoDepartment of Pharmacology, School of Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
Hang YaoJiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology, Nanjing Medical University, Nanjing, 211166, China.
Fangfang WuDepartment of Pharmacology, School of Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
Xin DingDepartment of Pharmacology, School of Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
Qingyu ZhangDepartment of Pharmacology, School of Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
Jianhua DingJiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology, Nanjing Medical University, Nanjing, 211166, China.
Yi FanJiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology, Nanjing Medical University, Nanjing, 211166, China.
Ming LuJiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology, Nanjing Medical University, Nanjing, 211166, China.
Gang HuDepartment of Pharmacology, School of Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, China.ORCID 0000-0002-2864-4372
Nanjing University of Chinese Medicine · CNNanjing Medical University · CNNanjing Brain Hospital · CN

Funding

National Key R&D Program of China 2021ZD0202901National Natural Science Foundation of China 81991523National Natural Science Foundation of China 82104143Natural Science Foundation of Jiangsu Province BK20210683
6 · The paper itself

Abstract

Locus coeruleus (LC) dysfunction is involved in the pathophysiology of depression; however, the neural circuits and specific molecular mechanisms responsible for this dysfunction remain unclear. Here, it is shown that activation of tyrosine hydroxylase (TH) neurons in the LC alleviates depression-like behaviors in susceptible mice. The dorsolateral septum (dLS) is the most physiologically relevant output from the LC under stress. Stimulation of the LC

Indexed as

DepressionLocus CoeruleusAnimalsAntidepressive AgentsBrain-Derived Neurotrophic FactorFemaleMaleMiceNorepinephrineAntidepressive AgentsBrain-Derived Neurotrophic FactorNorepinephrineBDNF signalingdepression-like behaviordorsolateral septumlocus coeruleus

Identifiers

PMID38155473
PMCPMC10933643
OpenAlexW4390397319

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.