Evidence map›Paper›PMID 38155333›Full record

SynthesisBiological trace element research2024

Shining a Light on Selenium: a Meta-analysis of Supplementation in Multiple Sclerosis.

Mehrab Rahmani, Sina Pakkhesal, Saman Baharomid, Hanie Karimi, Reza Mosaddeghi-Heris, Mahnaz Talebi, Negar Aghaei, Alireza Rahimi-Mamaghani, Sarvin Sanaie, Amirreza Naseri

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Biological trace element research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Mehrab RahmaniStudent Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.ORCID https://orcid.org/0009-0000-0435-4226
Sina PakkhesalStudent Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.ORCID https://orcid.org/0000-0003-2540-6827
Saman BaharomidStudent Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.ORCID https://orcid.org/0009-0008-7946-6618
Hanie KarimiSchool of Medicine, Tehran University of Medical Sciences, Tehran, Iran.ORCID https://orcid.org/0000-0001-9941-0437
Reza Mosaddeghi-HerisNeurosciences Research Center (NSRC), Tabriz University of Medical Sciences, Tabriz, Iran.ORCID https://orcid.org/0000-0002-3353-1102
Mahnaz TalebiNeurosciences Research Center (NSRC), Tabriz University of Medical Sciences, Tabriz, Iran.ORCID https://orcid.org/0000-0002-7613-3913
Negar AghaeiFaculty of Medicine, Tabriz Medical Sciences, Islamic Azad University, Tabriz, Iran.ORCID https://orcid.org/0009-0003-5614-832X
Alireza Rahimi-MamaghaniClinical Research Development Unit of Tabriz Valiasr Hospital, Tabriz University of Medical Sciences, Tabriz, Iran.ORCID https://orcid.org/0009-0000-8020-2697
Sarvin SanaieNeurosciences Research Center (NSRC), Tabriz University of Medical Sciences, Tabriz, Iran. sarvin_so2000@yahoo.com.ORCID https://orcid.org/0000-0003-2325-5631
Amirreza NaseriStudent Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran. Amirx2eza@gmail.com.ORCID https://orcid.org/0000-0001-9723-0109
Tabriz University of Medical Sciences · IRIslamic Azad University of Tabriz · IRTehran University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multiple sclerosis (MS) is a chronic immune-mediated demyelinating disease of the central nervous system. Selenium is a trace element with significant antioxidant activity. This study aimed to seek evidence concerning selenium supplementation in MS. A systematic search was performed on PubMed, Web of Science, Scopus, and Embase databases to identify the studies assessing the consumption rate, efficacy, and safety of selenium and selenium-containing supplementations in MS patients. The meta-analysis was performed using the Comprehensive Meta-Analysis and the risk of bias was evaluated using the Joanna Briggs Institute's critical appraisal tools. A total of 9 studies were included, which consisted of six studies regarding the rate of selenium supplement consumption in MS patients, with a total sample size of 2381 patients. Based on the quantitative synthesis, 14.3% (95% CI, 12.8-16.0%; I

Indexed as

Dietary SupplementsMultiple SclerosisSeleniumAntioxidantsHumansOxidative StressAntioxidantsSeleniumDietary supplementsMeta-analysisMicronutrientsMultiple sclerosisSeleniumSystematic review

Identifiers

PMID38155333
OpenAlexW4390409888

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.