Evidence map›Paper›PMID 38155219›Full record

ArticleScientific reports2023

dTrmt10A impacts Hsp70 chaperone m

Alexandra E Perlegos, Xiuming Quan, Kirby M Donnelly, Hui Shen, Emily J Shields, Heidi Elashal, Kathy Fange Liu, Nancy M Bonini

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Alexandra E PerlegosNeuroscience Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Xiuming QuanDepartment of Biology, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Kirby M DonnellyDepartment of Biology, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Hui ShenSchool of Life Science and Technology, China Pharmaceutical University, Nanjing, 210009, Jiangsu, China.
Emily J ShieldsEpigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Heidi ElashalDepartment of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Kathy Fange LiuDepartment of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Nancy M BoniniNeuroscience Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. nbonini@sas.upenn.edu.
University of Pennsylvania · USChina Pharmaceutical University · CNPhiladelphia University · US

Funding

TRAINING PROGRAM IN CELL AND MOLECULAR BIOLOGYT32GM007229 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI BARTOLOMEI, MARISA S. · 1985 to 2023
$14.0M
Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
Drosophila Transgenic RNAi Resource ProjectR01GM084947 · NIGMS · HARVARD MEDICAL SCHOOL · PI PERRIMON, NORBERT · 2008 to 2019
$9.8M
DROSOPHILA GENOMICS RESOURCE CENTERP40OD010949 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Andrew Zelhof · 2012 to 2026
$9.4M
Molecular Genetic Insight into Neurodegenerative Disease from DrosophilaR35NS097275 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI BONINI, NANCY M · 2017 to 2024
$6.0M
Deciphering the molecular interplay of sleep and neurodegeneration with DrosophilaR01AG071777 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Nancy M Bonini, MATTHEW S KAYSER · 2022 to 2026
$3.1M
Coregulation of mRNA, tRNA, and rRNA species through RNA modificationsR35GM133721 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI LIU, FANGE · 2019 to 2023
$2.5M
The in vivo role of m6A RNA modification in Cellular Stress, Aging, and Neurological ­DiseaseF31AG063470 · NIA · UNIVERSITY OF PENNSYLVANIA · PI PERLEGOS, ALEXANDRA EMILY · 2019 to 2021
$124k
NIA NIH HHS F31 AG063470NIA NIH HHS F31-AG063470NIA NIH HHS R01 AG071777NIGMS NIH HHS R01 GM084947NIGMS NIH HHS R35 GM133721NIGMS NIH HHS R35-GM133721NIGMS NIH HHS T32 GM007229NIH HHS P40 OD010949NIH HHS P40 OD018537NINDS NIH HHS R35 NS097275NINDS NIH HHS R35-NS097275
6 · The paper itself

Abstract

Chronic cellular stress has a profound impact on the brain, leading to degeneration and accelerated aging. Recent work has revealed the vital role of RNA modifications, and the proteins responsible for regulating them, in the stress response. In our study, we defined the role of CG14618/dTrmt10A, the Drosophila counterpart of human TRMT10A a N

Indexed as

DrosophilaHSP70 Heat-Shock ProteinsAnimalsBrainHumansMethyltransferasesMolecular ChaperonesRNAHSP70 Heat-Shock ProteinsMethyltransferasesMolecular ChaperonesRNATRMT10A protein, human

Identifiers

PMID38155219
PMCPMC10754819
OpenAlexW4390345554

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.