Evidence map›Paper›PMID 38154764›Full record

ArticleBone2024

Quantitative

Victor B Kassey, Matthias Walle, Jonathan Egan, Diana Yeritsyan, Indeevar Beeram, Yaotang Wu, Brian D Snyder, Edward K Rodriguez, Jerome L Ackerman, Ara Nazarian

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bone, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. A CombinedAnnals of biomedical engineering · 2026
    Article
  2. Review
  3. Article
  4. QuantitativeJournal of magnetic resonance imaging : JMRI · 2024
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Victor B KasseyMusculoskeletal Translational Innovation Initiative, Carl J. Shapiro Department of Orthopaedic Surgery, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA; Department of Orthopaedic Surgery, Children's Hospital, Boston, MA 02115, USA; Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA 02129, USA; Harvard Medical School, Boston, MA 02115, USA.
Matthias WalleMusculoskeletal Translational Innovation Initiative, Carl J. Shapiro Department of Orthopaedic Surgery, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
Jonathan EganMusculoskeletal Translational Innovation Initiative, Carl J. Shapiro Department of Orthopaedic Surgery, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
Diana YeritsyanMusculoskeletal Translational Innovation Initiative, Carl J. Shapiro Department of Orthopaedic Surgery, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
Indeevar BeeramMusculoskeletal Translational Innovation Initiative, Carl J. Shapiro Department of Orthopaedic Surgery, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
Yaotang WuDepartment of Orthopaedic Surgery, Children's Hospital, Boston, MA 02115, USA; Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA 02129, USA; Harvard Medical School, Boston, MA 02115, USA.
Brian D SnyderMusculoskeletal Translational Innovation Initiative, Carl J. Shapiro Department of Orthopaedic Surgery, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA; Department of Orthopaedic Surgery, Children's Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA.
Edward K RodriguezMusculoskeletal Translational Innovation Initiative, Carl J. Shapiro Department of Orthopaedic Surgery, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA; Harvard Medical School, Boston, MA 02115, USA.
Jerome L AckermanAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA 02129, USA; Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA 02139, USA; Harvard Medical School, Boston, MA 02115, USA.
Ara NazarianMusculoskeletal Translational Innovation Initiative, Carl J. Shapiro Department of Orthopaedic Surgery, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA; Department of Orthopaedic Surgery, Yerevan State Medical University, Yerevan, Armenia; Harvard Medical School, Boston, MA 02115, USA. Electronic address: anazaria@bidmc.harvard.edu.
Beth Israel Deaconess Medical Center · USBoston Children's Hospital · USHarvard University · US

Funding

Assessment of Bone Composition Through a Novel Liquid/Solid State MRI MethodR00AR057093 · NIAMS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI NAZARIAN, ARA · 2012 to 2014
$730k
Assessment of Bone Composition Through a Novel Liquid/Solid State MRI MethodK99AR057093 · NIAMS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI NAZARIAN, ARA · 2010 to 2011
$181k
NIAMS NIH HHS K99 AR057093NIAMS NIH HHS R00 AR057093
6 · The paper itself

Abstract

backgroundOsteoporosis is characterized by low bone mineral density (BMD), which predisposes individuals to frequent fragility fractures. Quantitative BMD measurements can potentially help distinguish bone pathologies and allow clinicians to provide disease-relieving therapies. Our group has developed non-invasive and non-ionizing magnetic resonance imaging (MRI) techniques to measure bone mineral density quantitatively. Dual-energy X-ray Absorptiometry (DXA) is a clinically approved non-invasive modality to diagnose osteoporosis but has associated disadvantages and limitations. PURPOSE: Evaluate the clinical feasibility of phosphorus ( MATERIALS AND

methodsFifteen ex-vivo rat bones in three groups [control, ovariectomized (osteoporosis), and vitamin-D deficient (osteomalacia - hypo-mineralized) were scanned to compute BMD. A double-tuned (

resultsThree-dimensional

conclusionQuantitative measurements of BMD on ex-vivo rat femurs were successfully conducted on a 7 T preclinical scanner. This study suggests that quantitative measurements of BMD are feasible on humans in clinical MRI with suitable hardware, RF coils, and pulse sequences with optimized parameters within an acceptable scan time since human femurs are approximately ten times larger than rat femurs. As MRI provides quantitative in-vivo data, various systemic musculoskeletal conditions can be diagnosed potentially in humans.

Indexed as

Bone Diseases, MetabolicOsteoporosisAbsorptiometry, PhotonAnimalsBone and BonesBone DensityHumansMagnetic Resonance ImagingPhosphorusRatsX-Ray MicrotomographyPhosphorusBone mineral densityOsteoporosisRatRenal osteodystrophySolid state MR imaging

Identifiers

PMID38154764
PMCPMC10843610
OpenAlexW4390245707

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.