Evidence map›Paper›PMID 38154473›Full record

ArticleThe Thoracic and cardiovascular surgeon2024

Current Status of Cardiac Xenotransplantation: Report of a Workshop of the German Heart Transplant Centers, Martinsried, March 3, 2023.

Michael Schmoeckel, Matthias Längin, Bruno Reichart, Jan-Michael Abicht, Martin Bender, Sebastian Michel, Christine-Elena Kamla, Joachim Denner, Ralf Reinhard Tönjes, Reinhard Schwinzer and 4 more

Abstract read
In one paragraph

Article in The Thoracic and cardiovascular surgeon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Allogeneic, Xenogeneic, and Exogenic Hearts for Transplantation.Methodist DeBakey cardiovascular journal · 2025
    Review
  2. [Xenotransplantation of solid organs].Chirurgie (Heidelberg, Germany) · 2024
    Review
  3. Cardiac Xenotransplantation: A Narrative Review.Reviews in cardiovascular medicine · 2024
    Review
  4. Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Michael SchmoeckelHerzchirurgische Klinik und Poliklinik, LMU Klinikum, LMU München, Germany.
Matthias LänginKlinik für Anaesthesiologie, LMU Klinikum, LMU München, Germany.
Bruno ReichartDFG-Transregio-Sonderforschungsbereich TR127-Xenotransplantation, Walter-Brendel-Zentrum für Experimentelle Medizin, LMU München, Germany.
Jan-Michael AbichtKlinik für Anaesthesiologie, LMU Klinikum, LMU München, Germany.
Martin BenderKlinik für Anaesthesiologie, LMU Klinikum, LMU München, Germany.
Sebastian MichelHerzchirurgische Klinik und Poliklinik, LMU Klinikum, LMU München, Germany.
Christine-Elena KamlaHerzchirurgische Klinik und Poliklinik, LMU Klinikum, LMU München, Germany.
Joachim DennerDFG-Transregio-Sonderforschungsbereich TR127-Xenotransplantation, Walter-Brendel-Zentrum für Experimentelle Medizin, LMU München, Germany.
Ralf Reinhard TönjesDFG-Transregio-Sonderforschungsbereich TR127-Xenotransplantation, Walter-Brendel-Zentrum für Experimentelle Medizin, LMU München, Germany.
Reinhard SchwinzerDFG-Transregio-Sonderforschungsbereich TR127-Xenotransplantation, Walter-Brendel-Zentrum für Experimentelle Medizin, LMU München, Germany.
Georg MarckmannDFG-Transregio-Sonderforschungsbereich TR127-Xenotransplantation, Walter-Brendel-Zentrum für Experimentelle Medizin, LMU München, Germany.
Eckhard WolfDFG-Transregio-Sonderforschungsbereich TR127-Xenotransplantation, Walter-Brendel-Zentrum für Experimentelle Medizin, LMU München, Germany.
Paolo BrennerHerzchirurgische Klinik und Poliklinik, LMU Klinikum, LMU München, Germany.
Christian HaglHerzchirurgische Klinik und Poliklinik, LMU Klinikum, LMU München, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This report comprises the contents of the presentations and following discussions of a workshop of the German Heart Transplant Centers in Martinsried, Germany on cardiac xenotransplantation. The production and current availability of genetically modified donor pigs, preservation techniques during organ harvesting, and immunosuppressive regimens in the recipient are described. Selection criteria for suitable patients and possible solutions to the problem of overgrowth of the xenotransplant are discussed. Obviously microbiological safety for the recipient and close contacts is essential, and ethical considerations to gain public acceptance for clinical applications are addressed. The first clinical trial will be regulated and supervised by the Paul-Ehrlich-Institute as the National Competent Authority for Germany, and the German Heart Transplant Centers agreed to cooperatively select the first patients for cardiac xenotransplantation.

Indexed as

Graft SurvivalHeart TransplantationHeterograftsImmunosuppressive AgentsTransplantation, HeterologousAnimalsAnimals, Genetically ModifiedGermanyGraft RejectionHumansPatient SelectionRisk FactorsSwineTreatment OutcomeImmunosuppressive Agents

Identifiers

PMID38154473
PMCPMC11147670

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.