Evidence map›Paper›PMID 38154148›Full record

Observational studySleep medicine2024

A real-world observational study assessing relationships between excessive daytime sleepiness and patient satisfaction in obstructive sleep apnea.

Sairam Parthasarathy, Danielle Hyman, James Doherty, Ragy Saad, Jerry Zhang, Susan Morris, Lev Eldemir, Benjamin Fox, Mai Ka Ying Vang, Jessica Schroeder and 2 more

Open access · greenAbstract readObservational Study
In one paragraph

Observational study in Sleep medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Trial
  2. Clinical significance of sleepiness: an American Academy of Sleep Medicine position statement.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Sairam ParthasarathyUniversity of Arizona, Tucson, AZ, USA. Electronic address: spartha1@arizona.edu.
Danielle HymanJazz Pharmaceuticals, Palo Alto, CA, USA.
James DohertyJazz Pharmaceuticals, Palo Alto, CA, USA.
Ragy SaadJazz Pharmaceuticals, Palo Alto, CA, USA.
Jerry ZhangJazz Pharmaceuticals, Palo Alto, CA, USA.
Susan MorrisJazz Pharmaceuticals, Palo Alto, CA, USA.
Lev EldemirEvidation Health, San Mateo, CA, USA.
Benjamin FoxEvidation Health, San Mateo, CA, USA.
Mai Ka Ying VangEvidation Health, San Mateo, CA, USA.
Jessica SchroederEvidation Health, San Mateo, CA, USA.
Nell J MarshallEvidation Health, San Mateo, CA, USA.
Gregory S ParksJazz Pharmaceuticals, Palo Alto, CA, USA; Axsome Therapeutics, Inc., New York, NY, USA.
Evidation Health (United States) · USJazz Pharmaceuticals (United States) · USAxsome Therapeutics (United States) · USUniversity of Arizona · US

Funding

ACTIV Integration of Host-targeting Therapies for COVID-19 Administrative Coordinating CenterOT2HL156812 · NHLBI · RESEARCH TRIANGLE INSTITUTE · PI NOLEN, TRACY L, THOMAS, SONIA M · 2020 to 2024
$1270.7M
OTA-21-015A Post-Acute Sequelae of SARS-CoV-2 Infection Initiative: NYU Langone Health Clinical Science Core, Data Resource Core, and PASC Biorepository CoreOT2HL161847 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI GROSS, RACHEL SHARON, HORWITZ, LEORA · 2021 to 2025
$651.0M
NHLBI Maternal Morbidity and Mortality (3M) Administrative Coordinating CenterOT2HL158287 · NHLBI · WESTAT, INC. · PI Chanza Baytop · 2020 to 2026
$433.8M
Impact of Low Flow Nocturnal Oxygen Therapy On Hospital Readmission/Mortalityin Patients with Heart Failure and Central Sleep Apneal (LOFT-HF)UH3HL140144 · NHLBI · OHIO STATE UNIVERSITY · PI ABRAHAM, WILLIAM TOBER · 2019 to 2020
$5.5M
UAHS Sleep Research Center Construction GrantC06OD028307 · OD · UNIVERSITY OF ARIZONA · PI DAKE, MICHAEL D · 2019 to 2019
$5.0M
Translational Approaches to Health Disparities in Lung, Sleep, and PandemicsR25HL126140 · NHLBI · UNIVERSITY OF ARIZONA · PI FRANCISCO A MORENO, JANKO Z. NIKOLICH · 2014 to 2026
$4.6M
Medications for Obstructive Sleep Apnea to Improve Cognition in Children with Down Syndrome (MOSAIC DS)R33HL151254 · NHLBI · UNIVERSITY OF ARIZONA · PI COMBS, DANIEL · 2022 to 2025
$1.3M
Predictive Analytics and Peer-Driven Intervention for Guideline-based Care for Sleep ApneaR56HL138377 · NHLBI · UNIVERSITY OF ARIZONA · PI PARTHASARATHY, SAIRAM · 2017 to 2017
$763k
Impact of Low Flow Nocturnal Oxygen Therapy On Hospital Readmission/Mortalityin Patients with Heart Failure and Central Sleep Apneal (LOFT-HF)UG3HL140144 · NHLBI · OHIO STATE UNIVERSITY · PI ABRAHAM, WILLIAM TOBER · 2018 to 2018
$742k
DEtermining Capacity and Informing Down syndrome Assent Strategies (DECIDAS)R21HD109777 · NICHD · UNIVERSITY OF ARIZONA · PI COMBS, DANIEL · 2022 to 2023
$422k
NHLBI NIH HHS OT2 HL156812NHLBI NIH HHS OT2 HL158287NHLBI NIH HHS OT2 HL161847NHLBI NIH HHS R25 HL126140NHLBI NIH HHS R33 HL151254NHLBI NIH HHS R56 HL138377NHLBI NIH HHS UG3 HL140144NHLBI NIH HHS UH3 HL140144NICHD NIH HHS R21 HD109777NIH HHS C06 OD028307
6 · The paper itself

Abstract

OBJECTIVES/

backgroundTo estimate prevalence and severity of excessive daytime sleepiness among patients with obstructive sleep apnea (OSA) who were prescribed treatment; assess perception and satisfaction of OSA-related care; describe relationships between excessive daytime sleepiness, treatment adherence, and patient satisfaction. PATIENTS/

methodsA national population-based cross-sectional sample of US adults with clinician-diagnosed OSA was surveyed in January 2021 via Evidation Health's Achievement App. Patients completed the Epworth Sleepiness Scale, rated satisfaction with healthcare provider and overall OSA care, and reported treatment adherence. Covariates affecting excessive daytime sleepiness (average weekly sleep duration, treatment adherence, sleepiness-inducing medications, age, sex, body mass index, nasal congestion, smoking status, and comorbidities) were adjusted in multivariate regression models.

resultsIn 2289 participants (50.3 % women; 44.8 ± 11.1 years), EDS was highly prevalent (42 %), and was experienced by 36 % of patients with high positive airway pressure (PAP) therapy adherence. Each additional hour of nightly PAP use was associated with improved sleepiness (a 0.28-point lower Epworth score; p < 0.001). Excessive daytime sleepiness was associated with lower patient satisfaction with healthcare providers and overall care (OR [95 % CI] 0.62 [0.48-0.80] and 0.50 [0.39-0.64], respectively; p < 0.0001), whereas PAP adherence was associated with higher patient satisfaction (OR [95 % CI] 2.37 [1.64-3.43] and 2.91 [2.03-4.17]; p < 0.0001), after adjusting for confounders.

conclusionsIn a real-world population-based study of patients with OSA, excessive daytime sleepiness was highly prevalent and associated with poor patient satisfaction ratings. Better patient-centered care among patients with OSA may require interventions aimed at addressing excessive daytime sleepiness and treatment adherence.

Indexed as

Disorders of Excessive SomnolenceSleep Apnea, ObstructiveAdultCross-Sectional StudiesFemaleHumansMaleMiddle AgedPatient SatisfactionSleepinessApneaExcessive daytime sleepinessPatient satisfactionTreatment adherence

Identifiers

PMID38154148
PMCPMC10961719
OpenAlexW4390101932

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.