ArticlePlant & cell physiology2024
Arabidopsis HECT and RING-type E3 Ligases Promote MAPKKK18 Degradation to Regulate Abscisic Acid Signaling.
Article in Plant & cell physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 14 citations in OpenAlex.
- Pepper RING-type E3 ligase, CaANKR1, negatively regulates drought tolerance by modulating CaMAPK1 stability.The Plant journal : for cell and molecular biology · 2026Article
- A TaMYB2-TaMAP3K17 module enhances drought tolerance by promoting reactive oxygen species scavenging in wheat.aBIOTECH · 2026Article
- Genome-wide association analysis identifies novel genetic loci and candidate genes associated with seed dormancy in cultivated peanut.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Advances and opportunities for computational interrogation of plant proteins.The Plant journal : for cell and molecular biology · 2026Review
- Transcriptome Analysis Reveals the Role of Trehalose in Response to Polyethylene Terephthalate Nanoplastics Treatment in Foxtail Millet (Food science & nutrition · 2025Article
- Review
- Tomato mitogen-activated protein kinase: mechanisms of adaptation in response to biotic and abiotic stresses.Frontiers in plant science · 2025Review
- Overexpression of MEKK18 from Arabidopsis pumila in rice significantly enhances stress resistance at the early stage.PloS one · 2025Article
- Cullin-Conciliated Regulation of Plant Immune Responses: Implications for Sustainable Crop Protection.Plants (Basel, Switzerland) · 2024Review
- Research Progress in the Regulation of the ABA Signaling Pathway by E3 Ubiquitin Ligases in Plants.International journal of molecular sciences · 2024Review
- Article
- The HECT ubiquitin-protein ligases UPL1 and UPL2 are involved in degradation of Arabidopsis thaliana ACC synthase 7.Physiologia plantarumArticle
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Mitogen-activated protein kinase (MAPK) cascades are conserved signaling pathways that transduce extracellular signals into diverse cellular responses. Arabidopsis MAPKKK18 is a component of the MAPKKK17/18-MKK3-MPK1/2/7/14 cascades, which play critical roles in abscisic acid (ABA) signaling, drought tolerance and senescence. A very important aspect of MAP kinase signaling is both its activation and its termination, which must be tightly controlled to achieve appropriate biological responses. Recently, the ubiquitin-proteasome system (UPS) has received increasing attention as a key mechanism for maintaining the homeostasis of MAPK cascade components and other ABA signaling effectors. Previous studies have shown that the stability of MAPKKK18 is regulated by the UPS via the ABA core pathway. Here, using multiple proteomic approaches, we found that MAPKKK17/18 turnover is tightly controlled by three E3 ligases, UPL1, UPL4 and KEG. We also identified lysines 154 and 237 as critical for MAPKKK18 stability. Taken together, this study sheds new light on the mechanism that controls MAPKKK17/18 activity and function.
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Registered trials
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