Evidence map›Paper›PMID 38153637›Full record

ArticleMolecular diversity2024

Fluorinated 2-arylchroman-4-ones and their derivatives: synthesis, structure and antiviral activity.

Nadezhda Troshkova, Larisa Politanskaya, Irina Bagryanskaya, Igor Chuikov, Jiaying Wang, Polina Ilyina, Mikhail Mikhalski, Iana Esaulkova, Alexandrina Volobueva, Vladimir Zarubaev

Abstract read
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In one paragraph

Article in Molecular diversity, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Emerging perspectives: unraveling the anticancer potential of vitamin DNaunyn-Schmiedeberg's archives of pharmacology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nadezhda TroshkovaN.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of Russian Academy of Sciences, Ac. Lavrentiev Avenue, 9, Novosibirsk, Russian Federation, 630090.
Larisa PolitanskayaN.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of Russian Academy of Sciences, Ac. Lavrentiev Avenue, 9, Novosibirsk, Russian Federation, 630090. plv@nioch.nsc.ru.ORCID http://orcid.org/0000-0003-1374-8213
Irina BagryanskayaN.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of Russian Academy of Sciences, Ac. Lavrentiev Avenue, 9, Novosibirsk, Russian Federation, 630090.
Igor ChuikovN.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of Russian Academy of Sciences, Ac. Lavrentiev Avenue, 9, Novosibirsk, Russian Federation, 630090.ORCID http://orcid.org/0000-0002-8285-3669
Jiaying WangN.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of Russian Academy of Sciences, Ac. Lavrentiev Avenue, 9, Novosibirsk, Russian Federation, 630090.
Polina IlyinaSaint-Petersburg Pasteur Research Institute of Epidemiology and Microbiology, Mira Street, 14, Saint-Petersburg, Russian Federation, 197101.
Mikhail MikhalskiSaint-Petersburg Pasteur Research Institute of Epidemiology and Microbiology, Mira Street, 14, Saint-Petersburg, Russian Federation, 197101.
Iana EsaulkovaSaint-Petersburg Pasteur Research Institute of Epidemiology and Microbiology, Mira Street, 14, Saint-Petersburg, Russian Federation, 197101.ORCID http://orcid.org/0000-0002-3645-8342
Alexandrina VolobuevaSaint-Petersburg Pasteur Research Institute of Epidemiology and Microbiology, Mira Street, 14, Saint-Petersburg, Russian Federation, 197101.ORCID http://orcid.org/0000-0003-0839-852X
Vladimir ZarubaevSaint-Petersburg Pasteur Research Institute of Epidemiology and Microbiology, Mira Street, 14, Saint-Petersburg, Russian Federation, 197101.ORCID http://orcid.org/0000-0002-5224-3771

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A number of new biologically interesting fluorinated 2-arylchroman-4-ones and their 3-arylidene derivatives were synthesized based on the p-toluenesulfonic acid-catalyzed one-pot reaction of 2-hydroxyacetophenones with benzaldehydes. It was found that obtained (E)-3-arylidene-2-aryl-chroman-4-ones reacted with malononitrile under base conditions to form 4,5-diaryl-4H,5H-pyrano[3,2-c]chromenes. The structures of the synthesized fluorinated compounds were confirmed by

Indexed as

Antiviral AgentsHalogenationAnimalsChromansDogsInfluenza A virusMadin Darby Canine Kidney CellsStructure-Activity RelationshipAntiviral AgentsChromans4,5-Diaryl-4H,5H-pyrano[3,2-c]chromenesAnti-viral activityCycloadditionFluorinated flavanonesInfluenza virusp-Toluenesulfonic acid

Identifiers

PMID38153637

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.