Evidence map›Paper›PMID 38153589›Full record

ArticleHuman genetics2025

Impact of calmodulin missense variants associated with congenital arrhythmia on the thermal stability and the degree of unfolding.

Giuditta Dal Cortivo, Valerio Marino, Davide Zamboni, Daniele Dell'Orco

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Giuditta Dal CortivoDepartment of Neurosciences, Biomedicine, and Movement Sciences, Section of Biological Chemistry, University of Verona, Strada Le Grazie 8, 37134, Verona, Italy.
Valerio MarinoDepartment of Neurosciences, Biomedicine, and Movement Sciences, Section of Biological Chemistry, University of Verona, Strada Le Grazie 8, 37134, Verona, Italy.
Davide ZamboniDepartment of Neurosciences, Biomedicine, and Movement Sciences, Section of Biological Chemistry, University of Verona, Strada Le Grazie 8, 37134, Verona, Italy.
Daniele Dell'OrcoDepartment of Neurosciences, Biomedicine, and Movement Sciences, Section of Biological Chemistry, University of Verona, Strada Le Grazie 8, 37134, Verona, Italy. daniele.dellorco@univr.it.ORCID http://orcid.org/0000-0002-3724-3044
University of Verona · IT

Funding

Center for Critical Assessment of Genome InterpretationU24HG007346 · NHGRI · UNIVERSITY OF CALIFORNIA BERKELEY · PI BRENNER, STEVEN E, IOANNIDIS, NILAH MONNIER · 2020 to 2025
$3.8M
Fondo Sociale Europeo REACT EU PON "Ricerca e innovazione" 2014-2020Ministero dell'Istruzione, dell'Università e della Ricerca 201744NR8SMinistero dell'Istruzione, dell'Università e della Ricerca PRIN2017National Institute of Health (US) NIH U24 HG007346NHGRI NIH HHS U24 HG007346
6 · The paper itself

Abstract

Thermal denaturation profiles of proteins that bind several ligands may deviate from the single transition, making their thermodynamic description challenging. We report an empirical method that estimates melting temperatures (T

Indexed as

Arrhythmias, CardiacCalmodulinMutation, MissenseCalciumCircular DichroismHumansProtein DenaturationProtein StabilityProtein UnfoldingThermodynamicsCalciumCalmodulin

Identifiers

PMID38153589
PMCPMC12163107
OpenAlexW4390345982

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.