Evidence map›Paper›PMID 38153518›Full record

ArticleInternational journal of colorectal disease2023

Association between social background and implementation of postoperative adjuvant chemotherapy for older patients undergoing curative resection of colorectal cancers, sub-analysis of the HiSCO-04 study.

Tomoaki Bekki, Manabu Shimomura, Yasufumi Saito, Masahiro Nakahara, Tomohiro Adachi, Satoshi Ikeda, Yosuke Shimizu, Masatoshi Kochi, Yasuyo Ishizaki, Masanori Yoshimitsu and 10 more

Open access · greenAbstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in International journal of colorectal disease, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 10 institutions in 1 country.

Tomoaki BekkiDepartment of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Kasumi 1-2-3 Minami-Ku, Hiroshima, Japan.ORCID http://orcid.org/0000-0003-0155-2360
Manabu ShimomuraDepartment of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Kasumi 1-2-3 Minami-Ku, Hiroshima, Japan. mshimo@hiroshima-u.ac.jp.
Yasufumi SaitoDepartment of Surgery, Chugoku Rosai Hospital, Kure, Japan.
Masahiro NakaharaDepartment of Surgery, Onomichi General Hospital, Onomichi, Japan.
Tomohiro AdachiDepartment of Surgery, Hiroshima City North Medical Center Asa Citizens Hospital, Hiroshima, Japan.
Satoshi IkedaDepartment of Surgery, Hiroshima Prefectural Hospital, Hiroshima, Japan.
Yosuke ShimizuDepartment of Surgery, National Hospital Organization Kure Medical Center/Chugoku Cancer Center, Institute for Clinical Research, Kure, Japan.
Masatoshi KochiDepartment of Gastroenterological Surgery, National Hospital Organization Higashihiroshima Medical Center, Higashihiroshima, Japan.
Yasuyo IshizakiDepartment of Surgery, National Hospital Organization Hiroshima-Nishi Medical Center, Otake, Japan.
Masanori YoshimitsuDepartment of Surgery, Hiroshima City Hiroshima Citizens Hospital, Hiroshima, Japan.
Yuji TakakuraDepartment of Surgery, Chuden Hospital, Hiroshima, Japan.
Wataru ShimizuDepartment of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Kasumi 1-2-3 Minami-Ku, Hiroshima, Japan.
Daisuke SumitaniDepartment of Surgery, JR Hiroshima Hospital, Hiroshima, Japan.
Shinya KodamaDepartment of Surgery, Yoshida General Hospital, Akitakata, Japan.
Masahiko FujimoriDepartment of Surgery, Kure City Medical Association Hospital, Kure, Japan.
Mamoru OhedaDepartment of Surgery, Sera Central Hospital, Sera, Japan.
Hironori KobayashiDepartment of Surgery, Hiroshima Memorial Hospital, Hiroshima, Japan.
Shintaro AkabaneDepartment of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Kasumi 1-2-3 Minami-Ku, Hiroshima, Japan.
Takuya YanoDepartment of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Kasumi 1-2-3 Minami-Ku, Hiroshima, Japan.
Hideki OhdanDepartment of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Kasumi 1-2-3 Minami-Ku, Hiroshima, Japan.ORCID http://orcid.org/0000-0002-9066-1288
Hiroshima University · JPHiroshima City Asa Citizens Hospital · JPNational Hospital Organization · JPChugoku Rosai Hospital · JPHigashihiroshima Medical Center · JPHiroshima General Hospital · JPHiroshima Prefectural Hospital · JPKure Medical Center · JPNishida Hospital · JPOnomichi General Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAdjuvant chemotherapy is recommended following colorectal cancer resection based on risk of recurrence. In older patients, treatment decisions should consider recurrence rates and tolerability, as well as functional prognosis, residual disease, and social factors. This study aims to investigate factors, including social background, influencing implementation of postoperative adjuvant chemotherapy in older patients undergoing curative resection for colorectal cancer.

methodsThis multi-institutional prospective cohort study included 15 institutions belonging to the Hiroshima Surgical study group for Clinical Oncology. We analyzed 159 older patients aged ≥ 80 years, who underwent curative resection for stage III colorectal cancer between December 2013 and June 2018, as sub-analysis of the HiSCO-04 study.

resultsIn total, 62 (39.0%) patients underwent postoperative adjuvant chemotherapy. Four factors were significantly associated with its implementation: performance status < 2, Charlson Comorbidity Index < 2, prognostic nutritional index ≥ 40, and presence of a spouse or siblings as lifestyle supporters. No significant difference was found in the backgrounds between complete and incomplete postoperative adjuvant chemotherapy patients.

conclusionPerformance status, Charlson Comorbidity Index, nutritional status, and presence of a spouse or siblings as lifestyle supporters are possible factors influencing the implementation of postoperative adjuvant chemotherapy in older patients. To select appropriate treatment options, including postoperative adjuvant chemotherapy, it is essential to consider physical condition and comorbidities of older patients, thoroughly explain the situation to their families, and establish a support system to enhance understanding of the available treatment options.

Indexed as

Chemotherapy, AdjuvantColorectal NeoplasmsSocial SupportAged, 80 and overHumansLife StyleProspective StudiesColorectal cancerOlder patientsPostoperative adjuvant chemotherapySocial backgrounds

Identifiers

PMID38153518
OpenAlexW4390347024

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.