Evidence map›Paper›PMID 38153162›Full record

ArticleAndrology2025

Paternal and maternal preconception and maternal pregnancy urinary concentrations of parabens in relation to child behavior.

Jordana Leader, Lidia Mínguez-Alarcón, Paige L Williams, Jennifer B Ford, Ramace Dadd, Olivia Chagnon, David C Bellinger, Emily Oken, Antonia M Calafat, Russ Hauser and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Andrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
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  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 1 country.

Jordana LeaderDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.ORCID 0009-0006-0309-9140
Lidia Mínguez-AlarcónChanning Division of Network Medicine, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts, USA.
Paige L WilliamsDepartments of Biostatistics and Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Jennifer B FordDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Ramace DaddDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Olivia ChagnonDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
David C BellingerCardiac Neurodevelopment Program, Boston Children's Hospital, Boston, Massachusetts, USA.
Emily OkenDepartment of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts, USA.
Antonia M CalafatNational Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Russ HauserDepartments of Environmental Health and Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Joseph M BraunDepartment of Epidemiology, Brown University, Providence, Rhode Island, USA.
Harvard University · USBoston Children's Hospital · USBrigham and Women's Hospital · USBrown University · USCenters for Disease Control and Prevention · USMassachusetts Department of Public Health · US

Funding

Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI JAIME ELIZABETH HART · 1985 to 2026
$44.6M
PCBs, Phthalates and Male Reproductive HealthR01ES009718 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI HAUSER, RUSS B · 1999 to 2018
$11.6M
Maternal and Paternal Preconception Environmental Exposures and Children's HealthR01ES027408 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI BRAUN, JOSEPH M, HAUSER, RUSS B · 2018 to 2022
$3.0M
National Institute of Environmental Health Sciences (NIEHS) P30ES000002National Institute of Environmental Health Sciences (NIEHS) R01ES009718National Institute of Environmental Health Sciences (NIEHS) R01ES027408NIEHS NIH HHS P30 ES000002NIEHS NIH HHS R01 ES009718NIEHS NIH HHS R01 ES027408
6 · The paper itself

Abstract

backgroundEpidemiologic studies of the effects of parental preconception paraben exposures on child behavior are limited despite emerging evidence suggesting that such exposures may affect offspring neurodevelopment.

objectiveWe investigated whether maternal and paternal preconception and maternal pregnancy urinary concentrations of parabens were associated with child behavior.

methodsWe analyzed data from the Preconception Environmental exposure And Childhood health Effects Study, an ongoing prospective cohort of children aged 6-13 years and their parents. We estimated covariate-adjusted associations of log

resultsThis analysis included 140 mothers, 81 fathers, and 171 children (25 sets of twins); parents were predominantly non-Hispanic white (88% for both mothers and fathers). In single paraben models, higher paternal preconception urinary propyl and methyl paraben concentrations were associated with higher Internalizing Problem T-scores (propyl paraben

conclusionIn this cohort, paternal preconception urinary concentrations of propyl and methyl paraben were associated with worse parent-reported child behaviors.

Indexed as

Child BehaviorParabensPrenatal Exposure Delayed EffectsAdolescentAdultChildFemaleHumansMaleMaternal ExposurePaternal ExposurePregnancyProspective StudiesParabenspropylparabenchild neurobehaviorendocrine disrupting chemicalsparabenspaternal exposurepreconception exposurepregnancy exposure

Identifiers

PMID38153162
PMCPMC11211245
OpenAlexW4390346823

What OpenQuestion holds

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LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.