Evidence map›Paper›PMID 3815304›Full record

ArticleCancer1987

Comparison of carcinoembryonic antigen levels between portal and peripheral blood in patients with colorectal cancer. Correlation with histopathologic variables.

Y Tabuchi, H Deguchi, K Imanishi, Y Saitoh

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Cancer, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 3 pooled it
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 46 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Y Tabuchi
H Deguchi
K Imanishi
Y Saitoh
Kobe University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Correlation between carcinoembryonic antigen (CEA) levels of peripheral and portal blood, and eight histopathologic variables, was examined in 66 patients with colorectal cancer. The change in CEA levels in the portal blood of 40 patients during operation was also examined in relation to histopathologic variables. CEA levels of portal blood (with a mean of 26.6 ng/ml and positive rate greater than 5 ng/ml, 59.1%) were significantly higher than those of peripheral blood (8.1 ng/ml, 33.3%). Elevation of CEA levels in portal and peripheral blood was most highly correlated with the venous invasion. Although the levels in the portal blood were related to six other histopathologic variables including tumor size, tumor differentiation, node metastasis, lymphatic invasion, invasive layer of the colorectal wall, and Dukes' classification except tumor location. CEA levels rose from 19.4 ng/ml and 40% to 43.6 ng/ml and 90.2% respectively following operative stimuli to cancer lesions with venous invasion. However, the levels did not rise in the lesions without the invasion. CEA levels of peripheral blood were as low as 5 ng/ml in three out of eight patients with liver metastasis. However, the levels in portal blood were much greater than 5 ng/ml in all of the patients. These results suggest that CEA may be hematogenously drained by the portal system via the draining vein from the cancer cells in the invasive veins but not by the thoracic duct of the lymphatic system.

Indexed as

Portal VeinAdenocarcinomaCarcinoembryonic AntigenColonic NeoplasmsHumansLaparotomyLiver NeoplasmsLymphatic MetastasisNeoplasm InvasivenessNeoplasm StagingRectal NeoplasmsCarcinoembryonic Antigen

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.