ArticleHypertension (Dallas, Tex. : 1979)2024
Fetal Sexual Dimorphism and Preeclampsia Among Twin Pregnancies.
Article in Hypertension (Dallas, Tex. : 1979), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 5 citations in OpenAlex.
- Impact of inter-twin growth discordance on preeclampsia: based on ultrasonic estimated fetal weight.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Elevated Micro- and Nanoplastics Detected in Preterm Human Placentae.Research square · 2025Article
- Understanding preeclampsia from cutting edge knowledge-protecting maternal and fetal health.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Review
- First-trimester serum biomarkers in twin pregnancies and adverse obstetric outcomes-a single center cohort study.Archives of gynecology and obstetrics · 2024Article
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4 authors at 2 institutions in 1 country.
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Abstract
backgroundIn singleton pregnancies, fetal sexual dimorphism has been observed in hypertensive disorders of pregnancy, particularly preeclampsia, a morbid syndrome that increases the risk of adult-onset cardiovascular disease for mothers and their offspring. However, few studies have explored the effect of fetal sex on hypertensive disorders of pregnancy among twin pregnancies.
methodsWe conducted a retrospective cohort study of 1032 twin pregnancies between 2011 and 2022 using data from a perinatal database that recruits participants from 3 hospitals in Houston, TX. We categorized pregnancies based on fetal sex pairings into female/female, male/male, and female/male. Pregnancies with female/female pairs were used as our reference group. Our primary outcomes included gestational hypertension, preeclampsia, superimposed preeclampsia, and preeclampsia subtyped by gestational age of delivery. A modified Poisson regression model with robust error variance was used to calculate the relative risk and 95% CI for the association between fetal sex pairs and hypertensive disorders of pregnancy.
resultsAdjusted models of female/male pairs were associated with preterm preeclampsia (relative risk, 2.01 [95% CI, 1.15-3.53]) relative to those with female/female pairs. No associations with other hypertensive disorders of pregnancy were observed among pregnancies with male/male pairs compared with those with female/female fetal sex pairs.
conclusionsWe found some evidence of sexual dimorphism for preterm preeclampsia among female/male twin pairs. Additional research is needed to understand what biological mechanisms could explain these findings.
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