Evidence map›Paper›PMID 38152610›Full record

ArticleCurrent research in chemical biology2023

Synthesis and characterization of I-BET151 derivatives for use in identifying protein targets in the African trypanosome.

Adi Narayana Reddy Poli, Rebecca C Blyn, Gracyn Y Buenconsejo, Melvin Hodanu, Eric Tang, Channy Danh, Joel Cassel, Erik W Debler, Danae Schulz, Joseph M Salvino

Open access · hybridAbstract read
In one paragraph

Article in Current research in chemical biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Adi Narayana Reddy PoliMedicinal Chemistry, Molecular and Cellular Oncogenesis (MCO) Program, United States.
Rebecca C BlynDepartment of Biology, Harvey Mudd College, Claremont, CA, 91711, United States.
Gracyn Y BuenconsejoDepartment of Biology, Harvey Mudd College, Claremont, CA, 91711, United States.
Melvin HodanuDepartment of Biology, Harvey Mudd College, Claremont, CA, 91711, United States.
Eric TangDepartment of Biology, Harvey Mudd College, Claremont, CA, 91711, United States.
Channy DanhDepartment of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA, 19107, United States.
Joel CasselThe Wistar Cancer Center Molecular Screening, The Wistar Institute, Philadelphia, PA, 19104, United States.
Erik W DeblerDepartment of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA, 19107, United States.
Danae SchulzDepartment of Biology, Harvey Mudd College, Claremont, CA, 91711, United States.
Joseph M SalvinoMedicinal Chemistry, Molecular and Cellular Oncogenesis (MCO) Program, United States.
Harvey Mudd College · USThe Wistar Institute · USThomas Jefferson University · USOrganogenesis (United States) · US

Funding

X-Ray Crystallography and Macromolecular CharacterizationP30CA056036 · NCI · THOMAS JEFFERSON UNIVERSITY · PI Andrew Chapman · 1995 to 2026
$94.8M
Tumor Microenvironment and MetastasisP30CA010815 · NCI · WISTAR INSTITUTE · PI Luis J Montaner · 1985 to 2026
$75.9M
Chromatin Biology of the African TrypanosomeR01AI165840 · NIAID · THOMAS JEFFERSON UNIVERSITY · PI DEBLER, ERIK · 2022 to 2025
$2.8M
A NEW HYBRID DIFFRACTOMETER FOR MACROMOLECULAR CRYSTALLOGRAPHY AND SAXS AT TJUS10OD017987 · OD · THOMAS JEFFERSON UNIVERSITY · PI CINGOLANI, GINO · 2014 to 2014
$600k
Purchase of an Echo 650 acoustic liquid handler with Access workstationS10OD030245 · OD · WISTAR INSTITUTE · PI SALVINO, JOSEPH M · 2021 to 2021
$567k
Target Validation for I-BET151-Induced Differentiation in the African TrypanosomeR21AI154191 · NIAID · THOMAS JEFFERSON UNIVERSITY · PI DEBLER, ERIK · 2021 to 2022
$459k
NCI NIH HHS P30 CA010815NCI NIH HHS P30 CA056036NIAID NIH HHS R01 AI165840NIAID NIH HHS R21 AI154191NIH HHS S10 OD017987NIH HHS S10 OD030245
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

BromodomainChemical probesHuman African trypanosomiasisInhibitor

Identifiers

PMID38152610
PMCPMC10751876
OpenAlexW4388447362

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.