Evidence map›Paper›PMID 38152594›Full record

ArticleIJID one health2023

Rabies post-exposure prophylaxis delivery to ensure treatment efficacy and increase compliance.

Deborah Nadal, Katrin Bote, Ramesh Masthi, Ashwath Narayana, Yasmeen Ross, Ryan Wallace, Bernadette Abela

Abstract read
In one paragraph

Article in IJID one health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Deborah NadalDepartment of Humanities, Ca' Foscari University of Venice: Malcanton Marcorà, Dorsoduro 3484/D, 30123 Venice, Italy.
Katrin BoteDepartment of Control of Neglected Tropical Diseases, World Health Organization, Avenue Appia 20, 1202 Geneva, Switzerland.
Ramesh MasthiDepartment of Community Medicine at the Kempegowda Institute of Medical Sciences Hospital & Research Centre, Krishna Rajendra Road, 560004 Bengaluru, Karnataka, India.
Ashwath NarayanaDepartment of Community Medicine at the Kempegowda Institute of Medical Sciences Hospital & Research Centre, Krishna Rajendra Road, 560004 Bengaluru, Karnataka, India.
Yasmeen RossUS Centers for Disease Control and Prevention, Clifton Road 1600, 30333 Atlanta, GA, United States.
Ryan WallaceUS Centers for Disease Control and Prevention, Clifton Road 1600, 30333 Atlanta, GA, United States.
Bernadette AbelaDepartment of Control of Neglected Tropical Diseases, World Health Organization, Avenue Appia 20, 1202 Geneva, Switzerland.

Funding

World Health Organization 001
6 · The paper itself

Abstract

Objectives: Since rabies is lethal once symptoms appear, its prevention including community awareness, mass dog vaccination and post-exposure prophylaxis (PEP) is crucial. Although safe and potent rabies vaccines have long been available, the global rabies burden is still high and access to adequately-delivered PEP remains challenging. Here we offer healthcare providers up-to-date, simple, exhaustive, visual guidance on how to perform PEP steps correctly. Protocol: PEP consists of 1) washing the wound with water and soap for 15 min, 2) assessing the need for rabies biologicals based on specific criteria; 3) administering, if required, rabies immunoglobulin or monoclonal antibodies deep in and around all wounds; 4) starting, if necessary, the WHO-recommended intradermal 1-week vaccination regimen; 5) informing patients adequately throughout the PEP process to increase compliance and avoid dangerous misconceptions about animal bite treatment and rabies risk. Discussion: The intradermal 1-week vaccination regimen recommended by WHO is as safe as other regimens but carries important cost-, dose- and time-sparing benefits. As fundamental as the correct administration of rabies biologicals is clear doctor-patient communication and sharing of up-to-date knowledge among healthcare professionals. Conclusions: This resource will help ensuring that no life is lost to rabies, an incurable yet preventable disease.

Indexed as

Intradermal vaccinationRabies immunoglobulinRabies post-exposure prophylaxisRabies vaccineRisk assessmentWound treatment

Identifiers

PMID38152594
PMCPMC10752235

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.