Evidence map›Paper›PMID 38152275›Full record

ArticleVeterinary world2023

Evaluation of the therapeutic efficacy of

Aparna Tripathy, Archana Parampalli Raghavendra, Babi Dutta, Sudarshan Surendran

Open access · goldAbstract read
In one paragraph

Article in Veterinary world, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Aparna TripathyDivision of Physiology, Department of Basic Medical Sciences, MAHE, Manipal, Karnataka, India.
Archana Parampalli RaghavendraDivision of Physiology, Department of Basic Medical Sciences, MAHE, Manipal, Karnataka, India.
Babi DuttaDivision of Biochemistry, Department of Basic Medical Sciences, MAHE, Manipal, Karnataka, India.
Sudarshan SurendranDepartment of Clinical Anatomy and Medical Imaging, American University of Antigua College of Medicine, Antigua.
Manipal Academy of Higher Education · INAmerican University of Antigua · AG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Aim: Cisplatin (CP) is a preferred drug for cancer treatment but it has dose-dependent side effects. Materials and Methods: Female Wistar rats (n = 30) were randomly divided into five groups (n = 6/group). The normal control (NC) group received no treatment. The CP control group received CP (7 mg/kg.b.w. ip, single dose) and the drug control group (VACE-650) received VACE (650 mg/kg b.w. oral, daily) for 7 days. Both groups received a single dose of CP (7 mg/kg b.w. ip), followed by 350 and 650 mg/kg.b.w. of VACE daily orally (CPVACE-350 and CPVACE-650 groups, respectively) for 7 days. Results: After a single dose of CP (7 mg/kg b.w.), the red blood cells (RBC), hematocrit (HCT), white blood cells (WBC), and platelets significantly decreased. In the VAC-350 group, the reduction in total WBC count was less than that in the VAC-650 group on the 3 Conclusion: Our findings showed that VACE can mitigate CP-induced damage to peripheral blood cells at lower doses.

Indexed as

cisplatinhematotoxicityratsVitex agnus-castus

Identifiers

PMID38152275
PMCPMC10750742
OpenAlexW4388340552

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.