Evidence map›Paper›PMID 38152138›Full record

ArticleFrontiers in endocrinology2023

Identification of novel genes including

Birgit Weiss, Tim Ott, Philipp Vick, Julian C Lui, Ralph Roeth, Sebastian Vogel, Stephan Waldmüller, Sandra Hoffmann, Jeffrey Baron, Jan M Wit and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 10 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 3 countries.

Birgit WeissInstitute of Human Genetics, Heidelberg University, Heidelberg, Germany.
Tim OttDepartment of Zoology, University of Hohenheim, Stuttgart, Germany.
Philipp VickDepartment of Zoology, University of Hohenheim, Stuttgart, Germany.
Julian C LuiNational Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, United States.
Ralph RoethInstitute of Human Genetics, Heidelberg University, Heidelberg, Germany.
Sebastian VogelDepartment of Zoology, University of Hohenheim, Stuttgart, Germany.
Stephan WaldmüllerInstitute of Medical Genetics and Applied Genomics, University of Tübingen, Tübingen, Germany.
Sandra HoffmannInstitute of Human Genetics, Heidelberg University, Heidelberg, Germany.
Jeffrey BaronNational Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, United States.
Jan M WitDivision of Pediatric Endocrinology, Department of Pediatrics, Willem-Alexander Children's Hospital, Leiden University Medical Center, Leiden, Netherlands.
Gudrun A RappoldInstitute of Human Genetics, Heidelberg University, Heidelberg, Germany.
Heidelberg University · DEUniversity of Hohenheim · DENational Institutes of Health · USLeiden University Medical Center · NLUniversity of Tübingen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Very tall people attract much attention and represent a clinically and genetically heterogenous group of individuals. Identifying the genetic etiology can provide important insights into the molecular mechanisms regulating linear growth. We studied a three-generation pedigree with five isolated (non-syndromic) tall members and one individual with normal stature by whole exome sequencing; the tallest man had a height of 211 cm. Six heterozygous gene variants predicted as damaging were shared among the four genetically related tall individuals and not present in a family member with normal height. To gain insight into the putative role of these candidate genes in bone growth, we assessed the transcriptome of murine growth plate by microarray and RNA Seq. Two (

Indexed as

Body HeightDNA HelicasesAnimalsBone DevelopmentGrowth PlateHumansMaleMiceNerve Tissue ProteinsTretinoinDNA HelicasesNAV2 protein, humanNav2 protein, mouseNerve Tissue ProteinsTretinoinall-trans retinoic acidgrowth plateIFT140isolated tall statureNAV2oligogenic inheritanceXenopus

Identifiers

PMID38152138
PMCPMC10752378
OpenAlexW4389626903

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.