SynthesisThe journal of nutrition, health & aging2023
Global Prevalence and Factors Associated with Frailty among Community-Dwelling Older Adults with Hypertension: A Systematic Review and Meta-Analysis.
Synthesis in The journal of nutrition, health & aging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 18 citations in OpenAlex.
- Changes in frailty, intensive blood pressure treatment, and risks of adverse clinical outcomes: a post hoc analysis of the SPRINT trial.BMC medicine · 2025Trial
- Risk of falls and syncope across frailty levels in hypertensive older adults: a longitudinal study.GeroScience · 2026Article
- Blood pressure satisfaction and antihypertensive medication adherence effects frailty transitions in older hypertensive patients.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Prehypertension and hypertension among older adults: prevalence, awareness, treatment, control and associated factors - findings from Iranian STEPS survey (2016 and 2021).Aging clinical and experimental research · 2026Article
- Association of Clinic Blood Pressure and Out-of-Clinic Blood Pressure Difference With Falls Among Older Adults With Hypertension.Hypertension (Dallas, Tex. : 1979) · 2026Article
- Analysis of the prevalence of frailty and its influential factors among the rural elderly from the Yi and Hani ethnic groups in border areas of Yunnan Province.BMC geriatrics · 2026Article
- Hypertension and depression coexistence and its association with frailty in older adults: a cross-sectional study.Dementia & neuropsychologia · 2026Article
- Healthy aging in frail older adults: Active aging project of a national survey.International journal of nursing studies advances · 2025Article
- Frailty in older adults: A systematic review of risk factors and early intervention pathways.Intractable & rare diseases research · 2025Review
- The relationship between frailty syndrome and quality of life in patients with hypertension: a multidimensional analysis.BMC geriatrics · 2025Article
- Development and validation of a model to predict the risk of frailty in older adults with panvascular disease.Frontiers in public health · 2025Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFrailty may increase the risk of adverse outcomes and the presence of comorbidities in hypertension. Understanding the prevalence of frailty in older adults with hypertension is of great importance, whereas estimates of the prevalence of frailty in this population vary greatly.
objectivesA systematic review and meta-analysis was conducted to estimate the pooled prevalence of frailty and prefrailty among community-dwelling older adults with hypertension, and to examine the risk factors associated with (pre)frailty in this population.
methodsPubMed, Web of Science, The Cochrane Library, EMBASE, and CINAHL were searched from the inception to May 10, 2023. Investigators assessed eligibility, extracted data, and evaluated methodological quality. The pooled prevalence of frailty and prefrailty was calculated using the random-effects model. Meta-regression analysis and subgroup analysis were conducted to explore sources of heterogeneity. Sensitivity analysis was undertaken by the leave-one-out method and by removing studies with moderate/high risk of bias. The Mantel-Haenszel or inverse variance method was used to estimate risk factors of frailty.
resultsA total of 14 studies met the inclusion criteria, involving 185,249 participants. The pooled prevalence in older adults with hypertension was 23% (95% CI 0.09-0.36) for frailty and 46% (95% CI 0.38-0.54) for prefrailty. The pooled prevalence of frailty was greater in studies with a higher proportion of females (24%, 95% CI 0.05-0.50), using multidimensional tools to define frailty (30%, 95% CI 0.10-0.51) and conducted in Western Pacific (27%, 95% CI 0.17-0.39). Age, female sex, depression, and previous hospitalizations were risk factors of frailty among older adults with hypertension.
conclusionFrailty and prefrailty are prevalent in community-dwelling older adults with hypertension, and limited risk factors are identified. This implicates the importance of frailty assessment integrated into the routine primary care for older adults with hypertension in community settings as well as the understanding of potential factors.
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