ArticleThe journal of nutrition, health & aging2023
The Longitudinal Relationship between Frailty, Loneliness and Cardiovascular Disease: A Prospective Cohort Study.
Article in The journal of nutrition, health & aging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.
- The impact of social relationships on the risk of stroke and post-stroke mortality: a systematic review and meta-analysis.BMC public health · 2024Pooled it
- Biopsychosocial frailty and the incident risk of cardio- and cerebrovascular diseases: an 8-year follow-up of the italian longitudinal study on aging.GeroScience · 2026Article
- Association of the cardiometabolic index and depressive symptoms with cardiovascular disease in cardiovascular-kidney-metabolic syndrome stages 0-3: A prospective cohort study.Scientific reports · 2026Article
- Loneliness, Chronic Conditions, and Healthcare Engagement in Japan: A Nationwide Cross-Sectional Study.JMA journal · 2026Article
- Changes in Frailty, Depression, and Loneliness among Stroke Survivors and Their Spouses.Cerebrovascular diseases (Basel, Switzerland) · 2026Article
- Association of Frailty and Its Trajectories With the Risk of Cardiovascular-Kidney-Metabolic Syndrome Progression: A Longitudinal Cohort Study.Geriatrics & gerontology international · 2026Article
- Association between loneliness trajectories and chronic diseases as well as chronic comorbidities among middle - aged and elderly chinese: based on the group - based trajectory modeling method.Scientific reports · 2026Observational
- Association of loneliness with incident cardiovascular diseases in middle-aged and older Chinese adults.PloS one · 2026Article
- Association of loneliness trajectories with chronic obstructive pulmonary disease, a cohort study from China.NPJ primary care respiratory medicine · 2025Article
- Combined and progressive effect of frailty and sarcopenia on the risk of cardiovascular disease in middle-aged and older adults.Journal of global health · 2025Article
- Association between cardiometabolic multimorbidity, body roundness index, and frailty index in Chinese middle-aged and older adults.The journal of nutrition, health & aging · 2025Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
objectivesPrevious studies had reported that frailty and loneliness were associated with increased risk of cardiovascular disease (CVD). The aim of present study was to evaluate the combined effect of frailty and loneliness on the risk of CVD.
methodsA total of 9,674 participants from the China Health and Retirement Longitudinal Study were included. Multivariate Cox proportional hazards regression model was used to explore the associations between frailty, loneliness and new-onset CVD, stroke and cardiac events.
resultsDuring the 7-year follow-up, a total of 1,758 respondents experienced CVD (including 584 stroke and 1,324 cardiac events). Compared to those without loneliness or frailty, individuals with loneliness alone, or with frailty alone, or with both loneliness and frailty were significantly associated with increased risk of CVD, with corresponding HRs (95%CIs) were 1.21(1.07-1.37), 1.57(1.32-1.86) and 1.78(1.52-2.10), respectively. Similarly, participants with loneliness alone, or with frailty alone, or with both loneliness and frailty were associated with higher risk of cardiac events. The significant associations were consistent in age subgroups (participants aged less or more than 60 years).
conclusionOur study indicated that there was a combined effect of effect of frailty and loneliness on the risk of CVD, stroke and cardiac events. These findings highlighted the importance of identifying loneliness and frailty, and intervening much earlier both in older and younger population.
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