ArticleAnalytical sciences : the international journal of the Japan Society for Analytical Chemistry2024
Fe-doped carbon dots: a novel fluorescent nanoprobe for cellular hypochlorous acid imaging.
Article in Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 7 citations in OpenAlex.
- Polyethyleneimine-Doped Carbon Quantum Dots as a Highly Sensitive Fluorescent Probe for HClO Sensing in Live Cell Imaging.Nanomaterials (Basel, Switzerland) · 2026Article
- Red Emissive Carbon Dots as Fluorescent Probe for Specific Sensing and Imaging of HCIO.Journal of fluorescence · 2025Article
- Facile preparation of fluorescent carbon dots from water caltrop shells and their application in amikacin sensing.RSC advances · 2025Article
- Preparation and Application of Carbon Dots Nanozymes.Antioxidants (Basel, Switzerland) · 2024Review
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6 authors at 1 institution in 1 country.
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Abstract
Real-time monitoring of hypochlorous acid (HClO) in biological systems is of great significance for exploring and regulating its pathological functions because abnormal production of HClO is closely related with many diseases, such as atherosclerosis, rheumatoid arthritis, and cancer. Herein, we developed a reliable fluorescent Fe-doped carbon dots (Fe-CDs) for the sensitive and selective detection of biological HClO using ferrocenecarboxylic acid and m-phenylenediamine as precursors through a one-step solvothermal procedure. The Fe-CDs exhibited excellent a wide HClO detection range from 20 nmol/L to 1000 nmol/L with corresponding limits of detection at 7.8 nmol/L. The sensing mechanism is based on the chemical oxidation of the hydroxyl groups on the surface of Fe-CDs by HClO. In addition, Fe-CDs also displayed high photoluminescence yield, excitation-independence emission, as well as good biocompatibility, enabling the successful imaging of endogenous and exogenous HClO in HeLa cells. These results revealed that Fe-CDs holds great promise as a robust fluorescent probe for investigating HClO-mediated biological events.
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Registered trials
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