ArticleNature biomedical engineering2024
Towards in vitro models for reducing or replacing the use of animals in drug testing.
Abstract read
In one paragraph
Article in Nature biomedical engineering, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Preclinical animal models for onchocerciasis and loiasis: A systematic review of applications in drug screening.PLoS neglected tropical diseases · 2026Pooled it
- Article
- Patient-derived organoids for precision oncology in colorectal cancer: from tumor modeling to clinical translation.Molecular cancer · 2026Review
- A Machine Vision-Guided Microphysiological Platform With Automated Microfluidics Enables Longitudinal Biomarker Monitoring and Emulation of Translationally Relevant Exposure Scenarios.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Side-by-Side Comparison of Different Thiol Bioconjugation Strategies for the Chemoselective Radiolabeling of Human Serum Albumin with Zirconium-89.ACS bio & med chem Au · 2026Article
- High-throughput histopathology for complex in vitro models.Cell reports methods · 2026Article
- Biocompatible designated Resin-3D-printed polymers exhibit reproductive toxicity prevented by Parylene-C.bioRxiv : the preprint server for biology · 2026Article
- Organoids, organ-on-a-chip, and microtumors: Biomimetic 3D tumor models advancing drug development and precision medicine.Acta pharmaceutica Sinica. B · 2026Review
- Transition to fetal calf serum-free culture enhances kidney proximal tubule cell bioenergetics and allows pharmacological applications.Cell and tissue research · 2026Article
- Advanced 3D cancer models for analyzing tumor-immune cell interaction and therapeutic response.Molecular cancer · 2026Review
- Physiologically relevant 3D CRISPR screening enhances mechanistic insight into chemical toxicity compared to 2D screening.Toxicology · 2026Article
- Intestinal Organoid-Based Mathematical Modeling Predicts Clinical Gastrointestinal Toxicity of Oral Oncology Drugs.CPT: pharmacometrics & systems pharmacology · 2026Article
- Engineering Organ-on-a-Chip Systems for Cancer Immunotherapy: Strategies and Assay Integration.Bioengineering (Basel, Switzerland) · 2026Review
- Advancing FDA New Approach Methodologies from animal models through digital twins.NPJ digital medicine · 2026Review
- Vascular STING activation facilitates NK cell anti-tumor immunity in small cell lung cancer.Cancer cell · 2026Article
- Bone Organoids: A Novel Tool for Modeling and Managing Skeletal Disorders in Diabetes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Multi-Task Cascade Forest Framework for Predicting Acute Toxicity across Species.Research (Washington, D.C.) · 2026Article
- Stimuli-responsive materials in organ-on-a-chip systems: from dynamic microenvironment modelling to functional readout.Frontiers in bioengineering and biotechnology · 2026Review
- Tissue Pharmacokinetics of Antisense Oligonucleotides.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Physiologically Relevant 3D CRISPR Screening Enhances Mechanistic Insight into Chemical Toxicity Compared to 2D Screening.bioRxiv : the preprint server for biology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
27 authors.
David M StresserQuantitative, Translational & ADME Sciences, AbbVie, North Chicago, IL, USA. david.stresser@abbvie.com.ORCID http://orcid.org/0000-0002-8577-1714
Anna K KopecInternational Consortium for Innovation and Quality in Pharmaceutical Development (IQ).
Philip HewittInternational Consortium for Innovation and Quality in Pharmaceutical Development (IQ).ORCID http://orcid.org/0000-0002-2741-3409
Rhiannon N HardwickInternational Consortium for Innovation and Quality in Pharmaceutical Development (IQ).ORCID http://orcid.org/0000-0001-9052-1309
Terry R Van VleetInternational Consortium for Innovation and Quality in Pharmaceutical Development (IQ).ORCID http://orcid.org/0000-0001-5364-7367
Prathap Kumar S MahalingaiahInternational Consortium for Innovation and Quality in Pharmaceutical Development (IQ).ORCID http://orcid.org/0000-0002-1958-1146
Denice O'ConnellInternational Consortium for Innovation and Quality in Pharmaceutical Development (IQ).
Gary J JenkinsQuantitative, Translational & ADME Sciences, AbbVie, North Chicago, IL, USA.
Rhiannon DavidInternational Consortium for Innovation and Quality in Pharmaceutical Development (IQ).ORCID http://orcid.org/0000-0003-2328-0298
Jessica GrahamInternational Consortium for Innovation and Quality in Pharmaceutical Development (IQ).ORCID http://orcid.org/0000-0002-3601-1743
Donna LeeInternational Consortium for Innovation and Quality in Pharmaceutical Development (IQ).ORCID http://orcid.org/0000-0003-1061-1385
Jason EkertInternational Consortium for Innovation and Quality in Pharmaceutical Development (IQ).
Aaron FullertonInternational Consortium for Innovation and Quality in Pharmaceutical Development (IQ).ORCID http://orcid.org/0009-0005-9380-9419
Remi VillenaveInternational Consortium for Innovation and Quality in Pharmaceutical Development (IQ).ORCID http://orcid.org/0000-0002-8934-5085
Piyush BajajInternational Consortium for Innovation and Quality in Pharmaceutical Development (IQ).
James R GossetInternational Consortium for Innovation and Quality in Pharmaceutical Development (IQ).
Sherry L RalstonInternational Consortium for Innovation and Quality in Pharmaceutical Development (IQ).
Manti GuhaInternational Consortium for Innovation and Quality in Pharmaceutical Development (IQ).
Alejandro Amador-ArjonaInternational Consortium for Innovation and Quality in Pharmaceutical Development (IQ).
Kainat KhanInternational Consortium for Innovation and Quality in Pharmaceutical Development (IQ).
Saket AgarwalInternational Consortium for Innovation and Quality in Pharmaceutical Development (IQ).ORCID http://orcid.org/0000-0002-1681-2842
Catrin HasselgrenInternational Consortium for Innovation and Quality in Pharmaceutical Development (IQ).
Xiaoting WangInternational Consortium for Innovation and Quality in Pharmaceutical Development (IQ).
Khary AdamsInternational Consortium for Innovation and Quality in Pharmaceutical Development (IQ).
Gaurav KaushikInternational Consortium for Innovation and Quality in Pharmaceutical Development (IQ).
Arkadiusz RaczynskiInternational Consortium for Innovation and Quality in Pharmaceutical Development (IQ).
Kimberly A HomanInternational Consortium for Innovation and Quality in Pharmaceutical Development (IQ), . homan.kimberly@gene.com.ORCID http://orcid.org/0000-0001-6103-0498
Funding
No grant is acknowledged in the PubMed record.
Abstract
PubMed holds no abstract for this paper.
Indexed as
Animal Testing AlternativesAnimalsDrug Evaluation, PreclinicalHumans
Identifiers
PMID
38151640What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.