Evidence map›Paper›PMID 38151612›Full record

ArticleMolecular neurobiology2024

Dual Effect of Carnosine on ROS Formation in Rat Cultured Cortical Astrocytes.

Fabiola Diniz, Belisa Parmeggiani, Gabriela Brandão, Bruna Klippel Ferreira, Monique Fonseca Teixeira, Emilio Luiz Streck, Silvia Olivera-Bravo, Luis Hector Barbeito, Patricia Fernanda Schuck, Ricardo Augusto de Melo Reis and 1 more

Abstract read
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Article in Molecular neurobiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 3 countries.

Fabiola DinizLaboratório de Erros Inatos do Metabolismo, Instituto de Bioquímica Médica Leopoldo de Meis, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Belisa ParmeggianiLaboratório de Erros Inatos do Metabolismo, Instituto de Bioquímica Médica Leopoldo de Meis, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Gabriela BrandãoLaboratório de Erros Inatos do Metabolismo, Instituto de Bioquímica Médica Leopoldo de Meis, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Bruna Klippel FerreiraLaboratório de Erros Inatos do Metabolismo, Instituto de Bioquímica Médica Leopoldo de Meis, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Monique Fonseca TeixeiraLaboratório de Erros Inatos do Metabolismo, Instituto de Bioquímica Médica Leopoldo de Meis, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Emilio Luiz StreckLaboratório de Doenças Neurometabólicas, Unidade Acadêmica de Ciências da Saúde, Universidade do Extremo Sul Catarinense, Criciúma, Brazil.
Silvia Olivera-BravoInstituto de Investigaciones Biológicas Clemente Estable, Montevideo, Uruguay.
Luis Hector BarbeitoInstitut Pasteur de Montevideo, Montevideo, Uruguay.
Patricia Fernanda SchuckLaboratório de Erros Inatos do Metabolismo, Instituto de Bioquímica Médica Leopoldo de Meis, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Ricardo Augusto de Melo ReisPrograma de Pós-Graduação em Ciências Biológicas:Biofísica, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Gustavo Costa FerreiraLaboratório de Erros Inatos do Metabolismo, Instituto de Bioquímica Médica Leopoldo de Meis, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil. gustavo.ferreira@bioqmed.ufrj.br.ORCID http://orcid.org/0000-0002-2892-8842
Universidade Federal do Rio de Janeiro · BRInstituto de Investigaciones Biológicas Clemente Estable · UYInstitut Pasteur de Montevideo · UYTulane University · USUniversidade do Extremo Sul Catarinense · BR

Funding

Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ) SEI-260003/002263/2020
6 · The paper itself

Abstract

Carnosine is composed of β-alanine and L-histidine and is considered to be an important neuroprotective agent with antioxidant, metal chelating, and antisenescence properties. However, children with serum carnosinase deficiency present increased circulating carnosine and severe neurological symptoms. We here investigated the in vitro effects of carnosine on redox and mitochondrial parameters in cultured cortical astrocytes from neonatal rats. Carnosine did not alter mitochondrial content or mitochondrial membrane potential. On the other hand, carnosine increased mitochondrial superoxide anion formation, levels of thiobarbituric acid reactive substances and oxidation of 2',7'-dichlorofluorescin diacetate (DCF-DA), indicating that carnosine per se acts as a pro-oxidant agent. Nonetheless, carnosine prevented DCF-DA oxidation induced by H

Indexed as

AstrocytesCarnosineCerebral CortexRats, WistarReactive Oxygen SpeciesAnimalsAnimals, NewbornCells, CulturedHydrogen PeroxideMembrane Potential, MitochondrialMitochondriaOxidation-ReductionRatsReceptors, N-Methyl-D-AspartateCarnosineHydrogen PeroxideReactive Oxygen SpeciesReceptors, N-Methyl-D-AspartateCarnosinemiaImidazolic dipeptidesMitochondriaNMDA receptorReactive oxygen species

Identifiers

PMID38151612
OpenAlexW4390274069

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.