Evidence map›Paper›PMID 38151603›Full record

ArticleCardiovascular and interventional radiology2024

Prospective Margin Estimates Predict Local Tumor Progression Following Microwave Ablation of Small Renal Masses.

Franklin Iheanacho, Nathaniel Rex, Karim Oueidat, Scott Collins, Grayson L Baird, DaeHee Kim, Gregory J Dubel, Bryan S Jay, Aaron W P Maxwell

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Article in Cardiovascular and interventional radiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Franklin IheanachoDepartment of Diagnostic Imaging, The Warren Alpert Medical School of Brown University, 593 Eddy Street, Providence, RI, 02903, USA.
Nathaniel RexDepartment of Diagnostic Imaging, The Warren Alpert Medical School of Brown University, 593 Eddy Street, Providence, RI, 02903, USA.
Karim OueidatDepartment of Diagnostic Imaging, The Warren Alpert Medical School of Brown University, 593 Eddy Street, Providence, RI, 02903, USA. Karim.oueidat7@gmail.com.ORCID http://orcid.org/0000-0003-3288-8975
Scott CollinsDepartment of Diagnostic Imaging, The Warren Alpert Medical School of Brown University, 593 Eddy Street, Providence, RI, 02903, USA.
Grayson L BairdDepartment of Diagnostic Imaging, The Warren Alpert Medical School of Brown University, 593 Eddy Street, Providence, RI, 02903, USA.
DaeHee KimDepartment of Diagnostic Imaging, The Warren Alpert Medical School of Brown University, 593 Eddy Street, Providence, RI, 02903, USA.
Gregory J DubelDepartment of Diagnostic Imaging, The Warren Alpert Medical School of Brown University, 593 Eddy Street, Providence, RI, 02903, USA.
Bryan S JayDepartment of Diagnostic Imaging, The Warren Alpert Medical School of Brown University, 593 Eddy Street, Providence, RI, 02903, USA.
Aaron W P MaxwellDepartment of Diagnostic Imaging, The Warren Alpert Medical School of Brown University, 593 Eddy Street, Providence, RI, 02903, USA.
Brown University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate the relationship between prospectively generated ablative margin estimates and local tumor progression (LTP) among patients undergoing microwave ablation (MWA) of small renal masses (SRMs). MATERIALS AND

methodsBetween 2017 and 2020, patients who underwent MWA for SRM were retrospectively identified. During each procedure, segmented kidney and tumor shapes were coregistered with intraprocedural helical CT images obtained after microwave antenna placement. Predicted ablation zone shape and size were then overlaid onto the resultant model, and a model-to-model distance algorithm was employed to calculate multiple ablative margin estimates. LTP was modeled as a function of each margin estimate by hazard regression. Models were evaluated using hazard ratios and Akaike information criterion. Receiver operating characteristic curve area under the curve was also estimated using Harrell's and Uno's C indices (HI and UI, respectively).

resultsOne hundred and twenty-eight patients were evaluated (median age 72.1 years). Mean tumor diameter was 2.4 ± 0.9 cm. LTP was observed in nine (7%) patients. Analysis showed that decreased estimated margin size as measured by first quartile (Q1; 25th percentile), maximum, and average ablative margin metrics was significantly associated with risk of LTP. For every one millimeter increase in Q1, maximum, and mean ablative margin, the hazard of LTP increased 67% (HR: 1.67; 95% CI = 1.25-2.20, UI = 0.93, HI = 0.77), 32% (HR: 1.32; 95% CI 1.09-1.60; UI = 0.93; HI = 0.76), and 48% (HR: 1.48; 95% CI 1.18-1.85; UI = 0.83; HI = 0.75), respectively.

conclusionProspectively generated ablative margin estimates can be used to predict the risk of local tumor progression following microwave ablation of small renal masses. LEVEL OF EVIDENCE 3: Retrospective cohort study.

Indexed as

Catheter AblationLiver NeoplasmsAgedHumansMicrowavesProspective StudiesRetrospective StudiesTreatment OutcomeMicrowave ablationSmall renal massesTumor recurrence

Identifiers

PMID38151603
OpenAlexW4390262961

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.