ArticleScientific reports2023
Automated tracking of cell migration in phase contrast images with CellTraxx.
Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Unsupervised Annotation Transfer in Phase-Contrast Microscopy Using a CycleGAN.Sensors (Basel, Switzerland) · 2026Article
- Proteomic Stability and Ex Vivo Compatibility of a Processed Phospholipoproteic Secretome-Derived Formulation.Pharmaceutics · 2026Article
- LFCT: A Benchmark Dataset for Low-Frame-Rate Cell Tracking in Long-Term Live-Cell Microscopy.bioRxiv : the preprint server for biology · 2026Article
- Progress and new challenges in image-based profiling.Molecular systems biology · 2026Review
- Influence of prey concentration, light intensity, and temperature on the growth and ingestion of the mixotrophic dinoflagellate Pyrophacus horologium, a predator of the harmful species Heterocapsa niei.Journal of phycology · 2026Article
- Accelerated discovery of cell migration regulators using label-free deep learning-based automated tracking.Science advances · 2026Article
- Delayed inferior vena cava-to-right ventricle bullet embolism following abdominal gunshot injury in somalia: a case report.Journal of cardiothoracic surgery · 2026Article
- Substrate elasticity controls fibroblast motility on non-oxidized PDMS under weak adhesion.Biophysics and physicobiology · 2026Article
- MDA-MB-231 cell morphology influences chemotactic sensing of CXCL12 gradients in type 1 bovine collagen matrix.PloS one · 2026Article
- Tui: A Multigenerational and Expert-Correctable Tracker for Cellular Dynamics.Computational and structural biotechnology journal · 2026Article
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- Article
- Extracellular Vesicles as Targeted Communicators in Complementary Medical Treatments.International journal of molecular sciences · 2025Review
- Article
- Scale selection and machine learning based cell segmentation and tracking in time lapse microscopy.Scientific reports · 2025Article
- Development of label-free cell tracking for discrimination of the heterogeneous mesenchymal migration.PloS one · 2025Article
- CellRomeR: an R package for clustering cell migration phenotypes from microscopy data.Bioinformatics advances · 2025Article
- Label-free live cell recognition and tracking for biological discoveries and translational applications.Npj imaging · 2024Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The ability of cells to move and migrate is required during development, but also in the adult in processes such as wound healing and immune responses. In addition, cancer cells exploit the cells' ability to migrate and invade to spread into nearby tissue and eventually metastasize. The majority of cancer deaths are caused by metastasis and the process of cell migration is therefore intensively studied. A common way to study cell migration is to observe cells through an optical microscope and record their movements over time. However, segmenting and tracking moving cells in phase contrast time-lapse video sequences is a challenging task. Several tools to track the velocity of migrating cells have been developed. Unfortunately, most of the automated tools are made for fluorescence images even though unlabelled cells are often preferred to avoid phototoxicity. Consequently, researchers are constrained with laborious manual tracking tools using ImageJ or similar software. We have therefore developed a freely available, user-friendly, automated tracking tool called CellTraxx. This software makes it easy to measure the velocity and directness of migrating cells in phase contrast images. Here, we demonstrate that our tool efficiently recognizes and tracks unlabelled cells of different morphologies and sizes (HeLa, RPE1, MDA-MB-231, HT1080, U2OS, PC-3) in several types of cell migration assays (random migration, wound healing and cells embedded in collagen). We also provide a detailed protocol and download instructions for CellTraxx.
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Registered trials
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