Evidence map›Paper›PMID 38151460›Full record

ArticleJournal of medicinal chemistry2024

Synthesis of α3β4 Nicotinic Acetylcholine Receptor Modulators Derived from Aristoquinoline That Reduce Reinstatement of Cocaine-Seeking Behavior.

Lisa E Rusali, Ana M Lopez-Hernandez, Kyle M Kremiller, Gauri C Kulkarni, Abhishek Gour, Carolyn J Straub, Malaika D Argade, Christian J Peters, Abhisheak Sharma, Lawrence Toll and 2 more

Open access · greenAbstract read
In one paragraph

Article in Journal of medicinal chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Lisa E RusaliDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Illinois Chicago, Chicago, Illinois 60612, United States.
Ana M Lopez-HernandezDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Illinois Chicago, Chicago, Illinois 60612, United States.
Kyle M KremillerDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Illinois Chicago, Chicago, Illinois 60612, United States.
Gauri C KulkarniDepartment of Anatomy and Cell Biology, College of Medicine, University of Illinois Chicago, Chicago, Illinois 60612, United States.
Abhishek GourDepartment of Pharmaceutics, College of Pharmacy, University of Florida, Gainesville, Florida 32610, United States.
Carolyn J StraubDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Illinois Chicago, Chicago, Illinois 60612, United States.ORCID 0000-0002-8976-5039
Malaika D ArgadeDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Illinois Chicago, Chicago, Illinois 60612, United States.ORCID 0000-0002-3401-1598
Christian J PetersDepartment of Anatomy and Cell Biology, College of Medicine, University of Illinois Chicago, Chicago, Illinois 60612, United States.
Abhisheak SharmaDepartment of Pharmaceutics, College of Pharmacy, University of Florida, Gainesville, Florida 32610, United States.
Lawrence TollBiomedical Science Department, Charles E. Schmidt College of Medicine, Stiles-Nicholson Brain Institute, Florida Atlantic University, Jupiter, Florida 33458, United States.
Andrea CippitelliBiomedical Science Department, Charles E. Schmidt College of Medicine, Stiles-Nicholson Brain Institute, Florida Atlantic University, Jupiter, Florida 33458, United States.
Andrew P RileyDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Illinois Chicago, Chicago, Illinois 60612, United States.ORCID 0000-0002-3878-0597
University of Illinois Chicago · USFlorida Atlantic University · USUniversity of Florida · US

Funding

Research Training in Natural Product Complementary and Integrative HealthT32AT007533 · NCCIH · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Joanna E Burdette, JIMMY ORJALA · 2013 to 2026
$4.3M
Synthesis and Evaluation of Alkaloids to Probe Membrane Receptors - Predoctoral SupplementR35GM147005 · NIGMS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Andrew Riley · 2022 to 2026
$2.3M
NCCIH NIH HHS T32 AT007533NIGMS NIH HHS R35 GM147005
6 · The paper itself

Abstract

Growing evidence suggests that inhibition of the α3β4 nicotinic acetylcholine receptor (nAChR) represents a promising therapeutic strategy to treat cocaine use disorder. Recently, aristoquinoline (

Indexed as

AlkaloidsCocaineQuinolinesReceptors, NicotinicAnimalsDrug-Seeking BehaviorNicotinic AntagonistsAlkaloidsaristoquinolineCocaineNicotinic AntagonistsQuinolinesReceptors, Nicotinic

Identifiers

PMID38151460
PMCPMC10872344
OpenAlexW4390297935

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.