Tempol improves aortic mechanics in a mouse model of hypertension.

Justyna A Niestrawska, Bart Spronck, Cristina Cavinato, Jay D Humphrey

Open access · hybridAbstract read

In one paragraph

Article in Journal of biomechanics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

0.4field-weighted citation impact, top 31% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 4 countries.

Justyna A NiestrawskaDepartment of Biomedical Engineering, Yale University, New Haven, CT, USA; Division of Macroscopic and Clinical Anatomy, Gottfried Schatz Research Center, Medical University of Graz, Graz, Austria.

Bart SpronckDepartment of Biomedical Engineering, Yale University, New Haven, CT, USA; Department of Biomedical Engineering, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, the Netherlands. Electronic address: b.spronck@maastrichtuniversity.nl.

Cristina CavinatoDepartment of Biomedical Engineering, Yale University, New Haven, CT, USA; Laboratoire de Mécanique et Génie Civile, Université Montpellier, Montpellier, France.

Jay D HumphreyDepartment of Biomedical Engineering, Yale University, New Haven, CT, USA.

Yale University · USMedical University of Graz · ATUniversité de Montpellier · FR

Funding

Modeling Multiscale Immuno-Mechanics in Aortic DiseaseR01HL155105 · NHLBI · YALE UNIVERSITY · PI HUMPHREY, JAY D., TELLIDES, GEORGE · 2022 to 2025

$2.0M

NHLBI NIH HHS R01 HL155105

6 · The paper itself

Abstract

Hypertension-induced arterial remodeling is thought to be a response to increases in both mechanical stress and oxidative stress. The superoxide dismutase mimetic Tempol has been shown to reduce adverse aortic remodeling in multiple murine models of hypertension but in the absence of a detailed assessment of the biaxial biomechanics. We show that concurrent treatment with Tempol in a common mouse model of systemic hypertension results in modest reductions in both wall thickening and circumferential material stiffness that yet work together to achieve a significant reduction in calculated aortic pulse wave velocity. Reducing elevated values of pulse wave velocity engenders multiple benefits to cardiovascular function.

Indexed as

HypertensionVascular StiffnessAnimalsBlood PressureCyclic N-OxidesDisease Models, AnimalMicePulse Wave AnalysisSpin LabelsCyclic N-OxidesSpin LabelstempolArteryBlood pressureInflammationMechanical stressOxidative stress

Identifiers

PMID38150954

DOI10.1016/j.jbiomech.2023.111911

PMCPMC10896091

OpenAlexW4389839731

What OpenQuestion holds

Textmetadata

LicenceTDM

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.